Hubert van den Bergh

Learn More
Exogenous administration of 5-aminolaevulinic acid (ALA) is becoming widely used to enhance the endogenous synthesis of protoporphyrin IX (PpIX) in photodynamic therapy (PDT) and fluorescence photodetection (PD). Recently, results have shown that the chemical modification of ALA into its more lipophilic esters circumvents limitations of ALA-induced PpIX(More)
· Background: Conventional photocoagulation of subfoveal choroidal neovascularization (CNV) is often accompanied by visual loss due to thermal damage to adjacent retinal structures. Photodynamic therapy (PDT) allows vascular occlusion by selective photochemical destruction of vascular endothelial cells only. In a pilot study we evaluated the use of PDT in(More)
In a recent issue, Cellular and Molecular Life Sciences published on the combination of photodynamic therapy (PDT) and anti-angiogenesis for the treatment of cancer [1]. In this paper, Bhuvaneswari and colleagues elegantly review this field. The idea behind combining these two therapeutic strategies is based on the observation that PDT can lead to vessel(More)
Light propagation in two-layered turbid media that have an infinitely thick second layer is investigated with time-resolved reflectance. We used a solution of the diffusion equation for this geometry to show that it is possible to derive the absorption and the reduced scattering coefficients of both layers if the relative reflectance is measured in the time(More)
A new multi-telescope scanning Raman lidar designed to measure the water vapor mixing ratio in the atmospheric boundary layer for a complete diurnal cycle with high resolution spatial (1.25 m) and temporal (1 s) resolutions is presented. The high resolution allows detailed measurements of the lower atmosphere and offers new opportunities for evaporation and(More)
The popular statistical theory of absolute diffuse reflectance of powders put forth by Melamed [J. Appl. Phys. 34, 560-570 (1963)] a quarter century ago has been re-examined thoroughly. Substantial errors in the physical formulation of the theory have been found and a corrected version is being presented. Some of Melamed's data fits to the theory are also(More)
Air pollution measurements are aimed at improving our understanding of the chemical properties of the atmosphere, addressing mainly three issues with very different space and time scales: • Measurement of critical or peak values of air pollutant in densely urbanized/industrialized sites. • Long term observation and trend analysis on air quality. •(More)
Frequent side effects of radical treatment modalities and the availability of novel diagnostics have raised the interest in focal therapies for localized prostate cancer. To improve the selectivity and therapeutic efficacy of such therapies, we developed a minimally invasive procedure, based on a novel polymeric photosensitizer prodrug sensitive to(More)
1. Introduction Photodynamic therapy (PDT) is the most promising therapy currently used for the treatment of choroidal neovascularization due to age-related macular degeneration [1]. To be useful as a therapeutic regimen, some selectivity between the target tissue and the neighbouring healthy structures must be achieved. This could be obtained by choosing a(More)