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Research on syntax in recent decades has focused on four overlapping topics: 1. the laws that govern the assignment of words to positions in a hierarchical syntactic structure; 2. the laws that govern the assignment of words to more than one position in hierarchical syntactic structure (movement or chain formation); 3. the interface between syntactic(More)
Preposed negation yes/no (yn)-questions like Doesn't John drink? necessarily carry the implicature that the speaker thinks John drinks, whereas non-preposed negation yn-questions like Does John not drink? do not necessarily trigger this implicature. Furthermore, preposed negation yn-questions have a reading " double-checking " Ô and a reading "(More)
Prosodic and syntactic constraints conflict with each other. This is particularly evident in the expression of focus, where the best position for main stress does not necessarily match the best syntactic position for the focused constituent. But focus and stress must match, therefore either stress or the focused constituent must renounce their best position(More)
We have studied the clinical presentation and course of a chronic inflammatory disease occurring in childhood and observed in 30 patients. The first symptoms were generally present at birth, except in a few patients where they were first noticed in early infancy. All the patients had the association of three main symptoms: neurological, cutaneous and(More)
IgG antibodies against the high mobility group (HMG) nonhistone chromosomal proteins HMG-1 and/or HMG-2 were detected in the sera of 49 (39%) of 126 antinuclear antibody (ANA)-positive patients with juvenile rheumatoid arthritis (JRA), by immunoblotting. Clinical diagnosis classified these patients in 2 major groups, 105 with pauciarticular-onset JRA and 21(More)
A set of 200 patients with early onset pauciarticular juvenile chronic arthritis (EOPA-JCA) from Munich (165) and Prague (35) was investigated for the subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14. In addition, the relationship of DRB1, DQA1, DQB1 and DPB1 alleles with iridocyclitis in patients with EOPA-JCA was investigated. Subtyping for DRB1*03 was(More)
DNA profiles (immunoprints) were generated for 120 patients suffering from early onset pauciarticular chronic arthritis (EOPA-JCA) and > 500 healthy controls utilizing highly polymorphic microsatellites in the vicinity of immunorelevant genes. Six T cell receptor (TCR) markers for the CD3D, TCRDVAJ, TEA, TCRBV6S1, BV6S3, BV6S7 and BV13S2 genes were(More)
Early-onset pauciarticular juvenile chronic arthritis (EOPA-JCA) has associations with different alleles of the MHC region (HLA-A2, DR5, 6, 8, DQA1*0401, *0501, *0601 and DPB1*0201). All susceptible DQA1 alleles carry an exclusive sequence motif. MHC-class II gene expression is controlled by 5' flanking upstream regulatory regions (URR). A hypervariable(More)