Huayi Huang

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PURPOSE In a previous gene expression array study, we identified some 300 genes that were differentially expressed in human epidermal growth factor receptor tyrosine kinase 2 (HER2)-positive versus HER2-negative breast cancer cells. We have now done validation experiments on a group of three cell membrane components that had previously not been implicated(More)
Number entry is an ubiquitous task in medical devices, but is implemented in many different ways, from decimal keypads to seemingly simple up/down buttons. Operator manuals often do not give clear and complete explanations , and all approaches have subtle variations, with details varying from device to device. This paper explores the design issues,(More)
Schistosomiasis, one of the most devastating parasitic diseases, is caused by Schistosoma japonicum (Sj) infection resulting in serious liver fibrosis. Interleukin- (IL-) 13, which is produced by TH2  cells, is a critical profibrotic cytokine found in various organs, including the liver. Tissue transglutaminase (tTG), a group of multifunctional enzymes,(More)
Although both the antiapoptotic function of survivin and vitamin D3 (VD3)-mediated cell growth inhibition and apoptosis have been extensively studied, it is not known whether survivin plays a role in VD3 compound-mediated cell growth inhibition and apoptosis induction. Using an isogenic model of MCF-7 breast adenocarcinoma cells (MCF-7E and MCF-7L sublines(More)
We report on a case study investigating current practice in the use of a programmable infusion pump. We start by for-malising an existing description of the procedure followed by nurses for setting up a commercial infusion pump obtained via observation and interview. We then compare and contrast this procedure with a formal description of the sequence of(More)
Cholecalciferol (D(3)) supplementation results in variable increases in serum 25(OH)D(3) levels, however, the influence of genetic polymorphisms on these variable responses is unclear. We measured serum 25(OH)D(3), 24,25(OH)(2)D(3), 1,25(OH)2D(3) and VDBP levels in 50 colorectal cancer (CRC) patients before and during 2,000 IU daily oral D(3)(More)
A systematic tool-based method is outlined that raises questions about the circumstances surrounding an incident: why it happened and what went wrong. The approach offers a practical and systematic way to apply a distributed cognition perspective to incident investigations , focusing on how available information resources (or the lack of them) may shape(More)