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TRAPPI tethers COPII vesicles by binding the coat subunit Sec23
The budding of endoplasmic reticulum (ER)-derived vesicles is dependent on the COPII coat complex. Coat assembly is initiated when Sar1-GTP recruits the cargo adaptor complex, Sec23/Sec24, by bindingExpand
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Altering the threshold of an excitable signal transduction network changes cell migratory modes
The diverse migratory modes displayed by different cell types are generally believed to be idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from amoeboid toExpand
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Efficient transformation of the medicinal mushroomGanoderma lucidum
Ganoderma lucidum is a well-known and important medicinal mushroom, but its genetic modification has not been reported. We developed an efficient procedure for isolation and regeneration ofExpand
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CaMV 35S promoter directs β-glucuronidase expression in Ganoderma lucidum and Pleurotus citrinopileatus
The cauliflower mosaic virus (CaMV) 35S promoter has been most commonly used in plant transformation studies, but its activity in mushrooms has not been reported. p301-b is a binary vector containingExpand
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A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum
A screen in Dictyostelium reveals that mTORC2 signaling participates in electrotaxis, as well as chemotaxis. Moving to that electric feel Cell movement can be guided by chemical gradientsExpand
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Auxilin facilitates membrane traffic in the early secretory pathway
In this study, a proteomic approach links the J-domain chaperone auxilin, which uncoats clathrin-coated vesicles, to the other major coat complexes in the cell (COPII and COPI). Genetic andExpand
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mBET3 is required for the organization of the TRAPP complexes.
Large tethering complexes mediate the initial interaction of a transport vesicle with its target membrane. There are two forms of the multi-subunit tethering complex called TRAPP (TRAPPI and TRAPPII)Expand
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Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects
Significance Our studies establish a connection between two isolated observations that 1) statins, taken by millions to lower cholesterol, have antitumor activity and 2) Ras-induced macropinocytosisExpand
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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells.
The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show thatExpand
Laccase3-based extracellular domain provides possible positional information for directing Casparian strip formation in Arabidopsis
The Casparian strip (CS) is a tight junction-like structure formed by lignin impregnation on the walls of endodermal cells in plant roots. The CS membrane domain (CSDM), demarked by the CASPExpand