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Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila*
TLDR
The genetic characterization of two immune inducible serine proteases, MP1 and MP2, which act in a melanization cascade regulated by Spn27A are described, which plays an important role in augmenting the effectiveness of other immune reactions, thereby promoting resistance of Drosophila to microbial infection. Expand
Regulation and function of the melanization reaction in Drosophila
TLDR
Genetic studies in Drosophila have identified serine proteases and serpins that regulate activation of PO and melanization in vivo, and these studies have provided new insight into the role that melanization plays in fighting microbial infection. Expand
A serpin that regulates immune melanization in the respiratory system of Drosophila.
TLDR
Unexpectedly, it is found that tracheal melanization resulting from Spn77Ba disruption induces systemic expression of the antifungal peptide Drosomycin via the Toll pathway, which could represent an alarm mechanism that prepares the host in case a pathogen breaches epithelial defenses to invade internal tissues. Expand
Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation.
TLDR
It is demonstrated that the so far uncharacterized Serpin-28D (Spn28D, CG7219) regulates the proPO cascade in both hemolymph and tracheal compartments and supports a model in which Spn 28D confines PO availability by controlling its initial release, while Spn27A is rather limiting the melanization reaction to the wound site. Expand
Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
TLDR
Evidence of therapeutic potential for the selective PKC (protein kinase C) inhibitor sotrastaurin (STN) in preclinical models ofDLBCL is offered and it is found that STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. Expand
P2Y6 Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development
TLDR
P2Y6 receptor augments pro-inflammatory responses in macrophages and exhibits a pro-atherogenic role in hematopoietic cells, however, the overall impact of whole body P2Y 6 deficiency on atherosclerosis appears to be modest and could reflect additional roles of P2y6 in vascular disease pathophysiologies, such as aneurysm formation. Expand
Investigation of LINC00342 as a poor prognostic biomarker for human patients with non–small cell lung cancer
TLDR
It is found that LINC00342 was upregulated in the tissues, serum, and PBMC of patients with NSCLC and may be a potential diagnostic factor and a target for new therapies for future patients withNSCLC. Expand
Linc00221 modulates cisplatin resistance in non-small-cell lung cancer via sponging miR-519a.
TLDR
Linc00221 promotes cisplatin resistance in NSCLC through the downstream miR-519a/ZBTB5 signaling axis, which could be used as a potential diagnostic and therapeutic target for clinical cisplatoon-resistant NSclC patients. Expand
Development of Novel, 384-Well High-Throughput Assay Panels for Human Drug Transporters
TLDR
High-throughput transporter screening capability enabled a paradigm shift from studying transporter-related issues in the development space to identifying and dialing out these concerns early on in discovery for enhanced mechanism-based efficacy while circumventing DDIs and transporter toxicities. Expand
384-Well Multiplexed Luminex Cytokine Assays for Lead Optimization
TLDR
The development and validation of the 384-well Luminex cytokine assays enabled high-throughput screening of compounds in primary cells using cytokines as physiologically relevant readouts, and this miniaturized multiplexed technology platform allows for high- throughput biomarker profiling of biofluids from animal studies and patient samples for translational research. Expand
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