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Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis
Transcriptional changes in salamander cells suggest an innate immune response to the alga, with potential attenuation of NF-κB, and metabolic alterations indicative of modulation of insulin sensitivity. Expand
Step-wise assembly of the neonatal virome modulated by breastfeeding
It is shown that the colonization of the infant gut is stepwise, first mainly by temperate bacteriophages induced from pioneer bacteria, and later by viruses that replicate in human cells; this second phase is modulated by breastfeeding. Expand
Co-cultures of Oophila amblystomatis between Ambystoma maculatum and Ambystoma gracile hosts show host-symbiont fidelity
- Ryan R Kerney, Jasper Leavitt, E. Hill, Huanjia Zhang, Eunsoo Kim, J. Burns
- 14 January 2019
Data reveal a potential host-symbiont fidelity that allows the unique endosymbiosis to occur in A. maculatum and A. gracile hosts, and suggests the intracapsular algae are assimilating ammonia for nitrogen metabolism and may be undergoing a life-cycle transition. Expand
Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
This study provides the first proof-of-concept evidence that a previously unappreciated factor, gut glycosylation, is a force that may impact the vicious cycle between HIV infection, microbial translocation, and chronic inflammation. Expand
Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease.
- F. Bushman, Máire A. Conrad, +25 authors R. Baldassano
- Medicine, Biology
- Cell host & microbe
- 11 August 2020
In IBD + CDI, both metabolites associated with inflammation/tissue damage and fermentation products produced by C. difficile are detected, and the most discriminating metabolite found is isocaproyltaurine, which may be useful as a joint marker of the two disease processes. Expand
The dynamics of the stool virome in very early onset inflammatory bowel disease.
P perturbations to normal viral populations associated with VEO-IBD are document and provide a biomarker--Anelloviridae DNA levels--potentially useful for reporting the effectiveness of immunosuppression. Expand
Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro
The results demonstrate that the human gut microbial community diversity and population size is significantly impacted by triclosan at a high dose in vitro, and that the community is recoverable within this system. Expand
Author response: Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis
Comparative analysis of the gut microbiota cultured in vitro using a single colon versus a 3-stage colon experimental design.
- Jenni Firrman, LinShu Liu, +6 authors P. Van den Abbeele
- Applied microbiology and biotechnology
- 25 March 2021
A comparative analysis of the population dynamics and functional production of short-chain fatty acids was performed using the gut microbiota of the same donor cultured using a single vessel and a 3-stage colon system to provide valuable information on how culturing technique effects gut microbial composition and function. Expand