Huan-hua Qin

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Objective: Cytochrome P 450 3A4 (CYP3A4) plays a vital role in the oxidative metabolism of many xenobiotics. Some recent reports have provided circumstantial evidence in support of an association between a genetic polymorphism (A→G) in the 5′-flanking region (−290) of CYP3A4 and altered enzyme activity. We sought to determine whether genotyping patients for(More)
OBJECTIVE To establish a model of acoustically evoked short latency negative response (ASNR) in guinea pigs, a model of profound hearing loss with normal saccular functions, and verify the correlation between ASNR and vestibular evoked myogenic potential (VEMP). METHODS Thirty-two healthy guinea pigs were employed in the experiment, which were randomly(More)
OBJECTIVE To establish a model of ototoxicity in guinea pigs with acoustically evoked short latency negative response (ASNR) and verify the responsible organ of ASNR based on microscopic characteristics of basal membranes, saccules, utricles and ampulla canalis semicircularis of the inner ear. METHODS Total of 45 guinea pigs were employed in the(More)
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