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Biofilms are involved in 80% of human bacterial infections and are up to 1000 times more tolerant to antibiotics than their planktonic counterparts. To better understand the mechanism of bacteria-surface interactions, polydimethylsiloxane (PDMS) surfaces with microtopographic patterns were tested to study the effects of surface topography on bacterial(More)
Bacterial response to surface topography during biofilm formation was studied using 5 μm tall line patterns of poly (dimethylsiloxane) (PDMS). Escherichia coli cells attached on top of protruding line patterns were found to align more perpendicularly to the orientation of line patterns when the pattern narrowed. Consistently, cell cluster formation per unit(More)
Bacterial biofilms are ubiquitous and are the major cause of chronic infections in humans and persistent biofouling in industry. Despite the significance of bacterial biofilms, the mechanism of biofilm formation and associated drug tolerance is still not fully understood. A major challenge in biofilm research is the intrinsic heterogeneity in the biofilm(More)
Bacterial biofilms are a major cause of chronic infections and biofouling; however, effective removal of established biofilms remains challenging. Here we report a new strategy for biofilm control using biocompatible shape memory polymers with defined surface topography. These surfaces can both prevent bacterial adhesion and remove established biofilms upon(More)
2013 i Acknowledgements In the long process of completing this thesis, I would like to express my sincere appreciation to my adviser and committee chair, Professor Annemarie Schneider, who has the attitude and the substance of a true geographer. Her devotion to research and attention to detail continuously pushed me to produce better work. Without her(More)
Bacterial biofilms are highly tolerant to antimicrobials and play an important role in the development and spread of antibiotic resistance based on horizontal gene transfer due to close cell-to-cell contact. As an important surface property, topography has been shown to affect bacterial adhesion and biofilm formation. Here, we demonstrate that(More)
Forests are important to nutrient cycling, hydrology, climate and aesthetics in urban ecosystems. Effective forest management in urban environments requires detailed data on the spatial distribution and structure of urban forests, but the lidar which are best for mapping the complexity of these forests are often unavailable or prohibitively expensive for(More)
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