Huaihong Zhang

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BACKGROUND Few data are available regarding the use of tenofovir disoproxil fumarate (TDF) during pregnancy for the prevention of mother-to-child transmission of hepatitis B virus (HBV). METHODS In this trial, we included 200 mothers who were positive for hepatitis B e antigen (HBeAg) and who had an HBV DNA level higher than 200,000 IU per milliliter.(More)
To enhance site-specific intracellular delivery against the folate receptor, a drug carrier was designed and synthesized by bioconjugation of folic acid (FA) to β-cyclodextrins (β-CD) through a poly(ethylene glycol) (PEG) spacer from "click chemistry" strategy. The resulted conjugates were confirmed by (1)H NMR and IR spectroscopy. Host-guest interactions(More)
A blue-emitting organic compound, 9-hydroxyl-3-hydroxyethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (I), was synthesized by the reaction of 2-amino-3-hydroxylpridine with 2-acetylbutyrolactone. The crystal of the title compound in larger size was reported for the first time through the slow evaporation method. The whole molecule in the crystal is(More)
In the crystal structure of the mononuclear title complex, [Ni(C(10)H(9)N(2)O(2))(2)(H(2)O)], the Ni(II) ion is five-coordinated in a distorted square-pyramidal geometry by two N atoms and two O atoms from 2,3-dimethyl-4-oxopyrido[1,2-a]pyrimidin-9-olate ligands and one O atom from a water mol-ecule. O-H⋯O hydrogen bonds between the coordinated water(More)
In the title complex, [Cu(C(14)H(13)N(2)O(2))(2)], the Cu(II) ion is located on a crystallographic inversion center. The complex thus adopts a square-planar trans-[CuN(2)O(2)] coordination geometry, with the Cu(II) ion coordinated by two 2-meth-oxy-6-(3-pyridylmethyl-imino-meth-yl)phenolate (Schiff base) ligands. The aryl and pyridyl rings in the Schiff(More)
In the title mononuclear complex, [Cu(C(13)H(10)ClN(2)O)(H(2)O)]-NO(3)·H(2)O, the Cu(II) atom is four-coordinated by two N atoms and one O atom of the tridentate Schiff base ligand and one O atom from the coordinated water mol-ecule in a slightly distorted square-planar configuration. The nitrate ion inter-acts with the copper center [Cu1⋯O3 = 2.579 (4) Å].(More)
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