Huaiguo Xue

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The excessive activation of the N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in the neuropathology of various neurodegenerative disorders. In this study, NO was found to mediate glutamate-induced excitotoxicity in primary cultured neurons. Compared with the NO synthase (NOS) inhibitor,(More)
Heptylene-linked bis-(9-amino-1,2,3,4-tetrahydroacridine) (bis(7)-tacrine) is a potential palliative therapeutic agent for Alzheimer's disease (AD), on the basis of its superior acetylcholinesterase (AChE) inhibition and memory-enhancing potency relative to tacrine. In this study we report that bis(7)-tacrine exhibits a potentially complementary central(More)
Stimulus-responsive microporous solid thin films were successfully fabricated by simple molecular self-assembly via an amphiphilic block polymer, polystryene–b–polyacrylic acid (PS–b–PAA). The solid thin films exhibit different surface morphologies in response to external stimuli, such as environments with different pH values in aqueous solutions. The(More)
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