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AIM To evaluate the efficacies of six derivatives of Compound 2, a novel YycG histidine kinase inhibitor with the thiazolidione core structure in the treatment of medical device-related biofilm infections. METHODS The minimal inhibitory concentration (MIC) of the derivatives was determined using the macrodilution broth method, and the minimal bactericidal(More)
The high-order schemes have attracted more and more attention in computational fluid dynamics (CFD) simulations. As a kind of high-order schemes, weighted compact nonlinear schemes (WCNSs) have been widely applied in large eddy simulations, direct numerical simulations etc. However, due to the computational complexity, WCNSs require high-performance(More)
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