Author pages are created from data sourced from our academic publisher partnerships and public sources.
Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
Purpose: Although clinical studies have shown promise for targeting programmed cell death protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the factors that predict… Expand
Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation
Purpose: We investigated the incidence of concomitant epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements in Chinese patients with non–small cell… Expand
Clinicopathologic and Molecular Features of Epidermal Growth Factor Receptor T790M Mutation and c-MET Amplification in Tyrosine Kinase Inhibitor-resistant Chinese Non-small Cell Lung Cancer
- Hua-jun Chen, T. S. Mok, +4 authors Y. Wu
- Biology, Medicine
- Pathology & Oncology Research
- 21 April 2009
To investigate the clinicopathologic and molecular features of the T790M mutation and c-MET amplification in a cohort of Chinese non-small cell lung cancer (NSCLC) patients resistant to epidermal… Expand
Structural and functional cerebral impairments in cirrhotic patients with a history of overt hepatic encephalopathy.
OBJECTIVE Diffuse brain atrophy has been observed in cirrhotic patients and recent reports have revealed the persistence of cognitive impairment after clinical resolution of overt hepatic… Expand
Brain structural and functional alterations in patients with unilateral hearing loss
- M. Yang, Hua-jun Chen, Bin Liu, Zhi-Chun Huang, G. Teng
- Psychology, Medicine
- Hearing Research
- 1 October 2014
Alterations of brain structure and functional connectivity have been described in patients with hearing impairments due to distinct pathogenesis; however, the influence of unilateral hearing loss… Expand
Aberrant functional connectivity of default-mode network in type 2 diabetes patients
AbstractObjectivesType 2 diabetes mellitus is associated with increased risk for dementia. Patients with impaired cognition often show default-mode network disruption. We aimed to investigate the… Expand
Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer.
- Q. Zhou, X. Zhang, +13 authors Y. Wu
- Journal of clinical oncology : official journal…
- 20 August 2011
PURPOSE Our aim was to determine whether abundance of epidermal growth factor receptor (EGFR) mutations in tumors predicts benefit from treatment with EGFR-tyrosine kinase inhibitors (TKIs) for… Expand
EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas.
BACKGROUND Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor heterogeneity in EGFR… Expand
Changes in the regional homogeneity of resting-state brain activity in minimal hepatic encephalopathy
- Hua-jun Chen, Xi-Qi Zhu, M. Yang, Bin Liu, G. Teng
- Psychology, Medicine
- Neuroscience Letters
- 17 January 2012
Resting-state functional magnetic resonance imaging (fMRI) has facilitated the study of spontaneous brain activity by measuring low-frequency oscillations in blood-oxygen-level-dependent signals.… Expand
A comprehensive review of uncommon EGFR mutations in patients with non-small cell lung cancer.
INTRODUCTION Patients with non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor (EGFR) mutations are a heterogeneous group exhibiting differential responses to EGFR… Expand