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Why are there hotspot mutations in the TP53 gene in human cancers?
The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that span ~190 different codons localized in the DNA-bindingExpand
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Balanced translocation t(3;18)(p13;q22.3) and points mutation in the ZNF407 gene detected in patients with both moderate non-syndromic intellectual disability and autism.
Intellectual disability (ID) is a common disease. While the etiology remains incompletely understood, genetic defects are a major contributor, which include mutations in genes encoding zinc fingerExpand
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Effects of androgen on the expression of brain aromatase cytopigment and nerve growth factor in neonatal rats with hypoxic-ischemic brain damage.
OBJECTIVE To study the effects of androgen on the expression of aromatase cytopigment P450 (AROM) and nerve growth factor (NGF) in the brain and brain ultrastructure in neonatal rats withExpand
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Protection of androgen against hypoxic-ischemic brain damage in neonatal rats and possible mechanisms.
OBJECTIVE Some research has shown that androgen has a neuroprotection against hypoxia-ischemia brain damage (HIBD). However, the relevant mechanism has not been fully elucidated. This study aimed toExpand
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[Effects of androgen on phosphacan and NG2 proteoglycan expression and neurite regeneration in neonatal rats with hypoxic-ischemic brain damage].
OBJECTIVE To study the effects of androgen on the expression of phosphacan and NG2 proteoglycan (NG2) and neurite regeneration in neonatal rats with hypoxic-ischemic brain damage (HIBD) and theExpand
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SCLEROSTIN NEUTRALISING ANTIBODY ENHANCES HEALING OF TIBIAL METAPHYSEAL DEFECT IN AN OVX RAT MODEL
tion of mineralization in SHAM group was shifted into lower mineralization (Fig. 2), suggesting that bone turnover in SHAM group might increase. The number of osteoblast was 1.5 fold higher and theExpand
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[Efficacy of different preparations of budesonide combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome: a comparative analysis].
OBJECTIVE To study the efficacy of different preparations of budesonide combined with pulmonary surfactant (PS) in improving blood gas levels and preventing bronchopulmonary dysplasia (BPD) inExpand
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[Dose-effect relationship between androgen and neural protection in neonatal rats with hypoxic-ischemic brain damage and adverse effects of androgen].
OBJECTIVE To explore brain-protective effect of androgen, its dose-effect relationship and long-term adverse reaction. METHOD Seventy two 3-day-old SD rats were randomized into androgen group (n =Expand
Epidemiological investigation and study on risk factors of stress urinary incontinence
Objective:To explore the risk factors of stress urinary incontinence (SUI).Methods:100 female patients with SUI and receiving survey and 100 healthy women were selected from Shanghai, a unifiedExpand
Therapeutic Effects of Prostaglandin E_1 Combined with Nitric Oxide on Ventricular Septal Defect Complicated by Pulmonary Hypertension
Objective To observe the therapeutic effects of intravenous prostaglandin E 1(PGE 1),inhaled nitric oxide(NO) and combined small doses of them for ventricular septal defect(VSD) complicated byExpand