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We present an unsupervised technique for detecting unusual activity in a large video set using many simple features. No complex activity models and no supervised feature selections are used. We divide the video into equal length segments and classify the extracted features into prototypes, from which a prototype-segment co-occurrence matrix is computed.(More)
Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent, currently in clinical trials, whose molecular mechanism of action remains unclear. Herein, we report that 2ME2 inhibits tumor growth and angiogenesis at concentrations that efficiently disrupt tumor(More)
Process checkpoint/restart is a very useful technology for process migration, load balancing, crash recovery, rollback transaction, job controlling and many other purposes. Although process migration has not yet been widely used and is not widely available commercial systems, the growing shift of computing facilities from supercomputers to networked(More)
Genome-wide association studies (GWAS) provide an important approach to identifying common genetic variants that predispose to human disease. A typical GWAS may genotype hundreds of thousands of single nucleotide polymorphisms (SNPs) located throughout the human genome in a set of cases and controls. Logistic regression is often used to test for association(More)
Proportional share resource management provides a flexible and useful abstraction for multiplexing timeshared resources. However, previous proportional share mechanisms have either weak proportional sharing accuracy or high scheduling overhead. We present VirtualTime Round-Robin (VTRR), a proportional share scheduler that can provide good proportional(More)
The phylogeography of the Y chromosome in Asia previously suggested that modern humans of African origin initially settled in mainland southern East Asia, and about 25,000–30,000 years ago, migrated northward, spreading throughout East Asia. However, the fragmented distribution of one East Asian specific Y chromosome lineage (D-M174), which is found at high(More)
Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and metabolic processes. Despite rapid progress in the understanding of these enzymes, a systematic investigation of the full spectrum of functionality of individual P450s, the interrelationship or networks connecting them, and the genetic control of each gene/enzyme is(More)
Tibetans live on the highest plateau in the world, their current population size is approximately 5 million, and most of them live at an altitude exceeding 3,500 m. Therefore, the Tibetan Plateau is a remarkable area for cultural and biological studies of human population history. However, the chronological profile of the Tibetan Plateau's colonization(More)
Genome-wide association studies (GWAS) provide an important approach for identifying common genetic variants that predispose to human disease. However, odds ratio (OR) estimates for the reported findings from GWAS discovery data are typically affected by a bias away from the null sometimes referred to the "winner's curse". Also standard confidence intervals(More)
Genetic diversity data, from Y chromosome and mitochondrial DNA as well as recent genome-wide autosomal single nucleotide polymorphisms, suggested that mainland Southeast Asia was the major geographic source of East Asian populations. However, these studies also detected Central-South Asia (CSA)- and/or West Eurasia (WE)-related genetic components in East(More)