Hua Zhang

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W. Lee, James N. Kochenderfer, +16 authors Crystal L Mackall
The Lancet
2015

BACKGROUND Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but… (More)

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

Yanli Wang, Hua Zhang, +13 authors Yongfeng Shang
Cell
2009

Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the… (More)

Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke.

Hua Zhang, Pranay Prabhakar, Robert Sealock, James E. Faber
Journal of cerebral blood flow and metabolism…
2010

Severity of stroke varies widely among individuals. Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown. We… (More)

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

Almut Grenz, Hartmut Osswald, +6 authors Holger K. Eltzschig
PLoS medicine
2008

BACKGROUND Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed.… (More)

Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation.

Lihua Li, Hua Zhang, Michel Varrin-doyer, Scott S. Zamvil, Alan S Verkman
FASEB journal : official publication of the…
2011

Aquaporin-4 (AQP4) deficiency in mice reduces neuroinflammation in experimental autoimmune encephalomyelitis (EAE) produced by active immunization with myelin oligodendrocyte glycoprotein peptide… (More)

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

Claude Sportés, Frances T Hakim, +17 authors Crystal L Mackall
The Journal of experimental medicine
2008

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating… (More)

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

Steven L Highfill, Yongzhi K. Cui, +5 authors Crystal L Mackall
Science Translational Medicine
2014

Suppression of the host’s immune system plays a major role in cancer progression. Tumor signaling of programmed death 1 (PD1) on T cells and expansion of myeloid-derived suppressor cells (MDSCs) are… (More)

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

Hua Zhang, Kevin S. Chua, +12 authors Crystal L Mackall
Nature Medicine
2005

CD4+CD25+ regulatory T (Treg) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking Treg cells develop severe autoimmune disease, and depletion of Treg cells in… (More)

PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons.

Laszlo Vutskits, Zahia Djebbara-Hannas, +5 authors Jozsef Z. Kiss
The European journal of neuroscience
2001

We show that the loss or inactivation of the polysialic acid (PSA) tail of neural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. The… (More)

Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.

Lukmanee Tradtrantip, Hua Zhang, +5 authors Alan S Verkman
Annals of neurology
2012

OBJECTIVE Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-immunoglobulin [Ig]G) against astrocyte water channel… (More)

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