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l-arginine improves dystrophic phenotype in mdx mice
TLDR
The results suggest that pharmacological activators of the NO pathway may constitute a realistic treatment for Duchenne and Becker muscular dystrophies. Expand
MALDI reveals membrane lipid profile reversion in MDX mice
TLDR
After confirmation by tandem mass spectrometry of the structure of these two phospholipids, their intensity ratio inversion was used to evidence a restoration of membrane lipid composition very similar to those of wild-type mice after the treatment of mdx mice with molsidomine, a NO donor. Expand
Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.
TLDR
Down-regulation of miR-34a inhibits mice mesangial cells (MMCs) proliferation in vitro and alleviates glomerular hypertrophy in vivo and GAS1 was proved to be the target of miGAS1 through luciferase report. Expand
Arginine butyrate: a therapeutic candidate for Duchenne muscular dystrophy
TLDR
In vivo and in vitro experiments demonstrated that the drug combination acts synergistically and constitute a proof of principle of the beneficial effects of arginine butyrate on muscular dystrophy. Expand
Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation.
TLDR
A model in which AMPK is activated byCVB3 infection and restricts viral replication by inhibiting the cellular lipid accumulation is suggested to inform a potential novel therapeutic strategy for CVB3-associated diseases. Expand
Role of ppGpp in Pseudomonas aeruginosa acute pulmonary infection and virulence regulation.
TLDR
This work reports that the ΔRS strain showed decreased cytotoxicity towards A549 human alveolar adenocarcinoma cell lines and led to reduced mortality, lung edema and inflammatory cell infiltration in a mouse model of acute pneumonia compared to wild-type PAO1 and the complemented strain ΔRS(++), and suggests that ppGpp is required for virulence regulation in P. aeruginosa. Expand
Hyperoside ameliorates glomerulosclerosis in diabetic nephropathy by downregulating miR-21.
TLDR
It is suggested that Hyp can ameliorate glomerulosclerosis in diabetic nephropathy by downregulating miR-21 to increase expression of its target, MMP-9. Expand
Nucleoside diphosphate kinase (Ndk): A pleiotropic effector manipulating bacterial virulence and adaptive responses.
TLDR
This review will provide a synopsis of the current knowledge regarding the biological properties and roles of Ndks in regulating bacterial virulence and adaptation and will discuss in depth the biological significance of Ndk during bacteria-host interactions. Expand
Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation.
TLDR
Results indicated that LasB could promote biofilm formation partly through the rhamnolipid-mediated regulation. Expand
Berberine Restricts Coxsackievirus B Type 3 Replication via Inhibition of c-Jun N-Terminal Kinase (JNK) and p38 MAPK Activation In Vitro
TLDR
Results suggest that BBR inhibits CVB3 replication through the suppression of JNK and p38 MAPK activation, shedding new light on the investigation of therapeutic strategies againstCVB3-induced viral myocarditis. Expand
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