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Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population
  • N. Wang, Li Wang, Chao Chen
  • Biology, Medicine
    European journal of cancer prevention : the…
  • 1 January 2015
TLDR
Genetic association results between 25 tag single-nucleotide polymorphisms and CRC in a case–control study of a Han Chinese population suggest that IL10, PSCA, IL1B, and SMAD7 are significantly correlated with CRC susceptibility in the Han Chinesepopulation.
Genetic polymorphisms and phenotypic analysis of drug-metabolizing enzyme CYP2C19 in a Li Chinese population.
TLDR
The results shed new light on CYP2C19 polymorphisms in Li individuals, which may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group.
Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population
TLDR
New evidence is provided for the association between TERT and GC susceptibility in the Chinese Han population and a protective effect of haplotype “CG” of the TERT gene, while the haplotypes “TA” increased GC risk is provided.
Genetic polymorphisms of pharmacogenomic VIP variants in the lhoba population of southwest China.
TLDR
The results complement pharmacogenomic data on the Lhoba ethnic group and may be helpful in the diagnosis of certain diseases in minorities.
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population
TLDR
Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM in the Han Chinese population, however, the functional significance of these polymorphisms needs further investigation.
Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study
TLDR
A significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population is suggested.
Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.
TLDR
The findings suggest that DUSP10 polymorphisms influence the risk of developing CRC in Han Chinese and emphasize that sex should be considered in the design and analysis of health studies and biomedical research.
EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population
TLDR
Investigating whether single nucleotide polymorphisms in multiple genetic variants were associated with COPD in a Chinese population from Hainan province indicated that rs10007052 in the RNF150 and rs3733829 in the EGLN2 gene were significantly associated with the risk of COPD.
Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
TLDR
SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women and increased the PCOS risk, according to the genotypic model analysis.
Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China
TLDR
This is the first study that systematically screened the polymorphisms of the whole CYP2C19 gene in Uyghur population and could be helpful for future personalized medicine studies in Uygur population generally.
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