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Glucose and other secretagogues are thought to activate a variety of protein kinases. This study was designed to unravel the sites of action of protein kinase A (PKA) and protein kinase C (PKC) in modulating insulin secretion. By using high time resolution measurements of membrane capacitance and flash photolysis of caged Ca(2+), we characterize three(More)
POU-homeodomain and LIM-homeodomain transcription factors are expressed in developing projection neurons within retina, inner ear, dorsal root ganglion, and trigeminal ganglion, and play synergistic roles in their differentiation and survival. Here, using immunohistochemistry, we present a comparative analysis of the spatiotemporal expression pattern of(More)
PURPOSE To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, using enhanced depth imaging spectral domain optical coherence tomography. METHODS The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). A detailed ophthalmic examination was performed including(More)
The prediction of an image quality metric (IQM) should be consistent with subjective human evaluation. As the human visual system (HVS) is critical to visual perception, modeling of the HVS is regarded as the most suitable way to achieve perceptual quality predictions. Sparse coding that is equivalent to independent component analysis (ICA) can provide a(More)
—This paper investigates the performance of IEEE 802.11 in multi-hop scenarios and shows how its aggressive behavior can throttle the spatial reuse and reduce bandwidth efficiency. An adaptive, layer-2, distributed coordination scheme for 802.11 using explicit medium access control (MAC) feedback is then proposed to pace the transmissions on adjacent nodes,(More)
A new generation of information systems that integrates knowledge base technology with database systems is presented for providing cooperative (approximate, conceptual, and asso-ciative) query answering. Based on the database schema and application characteristics, data are organized into Type Abstraction Hierarchies (TAHs). The higher levels of the(More)
Atoh1 encodes a basic helix-loop-helix (bHLH) transcription factor required for the development of the inner ear sensory epithelia, the dorsal spinal cord, brainstem, cerebellum, and intestinal secretory cells. In this study, to create a genetic tool for the research on gene function in the ear sensory organs, we generated an Atoh1-Cre knock-in mouse line(More)