Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier function.
- Xiaoyi Sun, A. Spencer, Hua Yang, E. Haxhija, D. Teitelbaum
- MedicineJPEN - Journal of Parenteral and Enteral…
- 1 November 2006
It is supported that lack of enteral nutrition, rather than absolute caloric levels, is responsible for many of the adverse effects of PN, and such changes increased with greater reduction of energy intake.
Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment.
- H. Koga, Hua Yang, J. Adler, E. Zimmermann, D. Teitelbaum
- MedicineSurgery
- 1 August 2008
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity
- Min Yu, Qimeng Wang, Hua Yang
- Medicine, BiologyInternational Journal on Biological Sciences
- 11 January 2018
It is found that AhR activation by FICZ attenuated the decreased TJ protein expression in the colonic mucosa of the DSS-induced mice, and AhR-activating factors might have potential as therapeutic agents for the treatment of patients with IBD.
Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse.
- Hua Yang, P. Antony, B. Wildhaber, D. Teitelbaum
- Medicine, BiologyJournal of Immunology
- 2004
Results show that KGF from IELs is an important factor for maintenance of intestinal epithelial cell proliferation and villus growth.
Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis
6-formylindolo (3,2-b) carbazole (Ficz) could down-regulate epithelial-derived IL-7 expression in mice with DSS-induced colitis and inhibit inflammation in the gastrointestinal tract of mice.
Reduced Severity of a Mouse Colitis Model with Angiotensin Converting Enzyme Inhibition
- A. Spencer, Hua Yang, E. Haxhija, B. Wildhaber, J. Greenson, D. Teitelbaum
- MedicineDigestive Diseases and Sciences
- 7 March 2007
ACE-I reduces the severity of DSS-induced colitis and reduces epithelial cell apoptosis, and the mechanism by which ACE-I reduced apoptosis is investigated.
High expression of DJ‐1 promotes growth and invasion via the PTEN‐AKT pathway and predicts a poor prognosis in colorectal cancer
DJ‐1 expression in CRC tissues was higher than that in normal colon tissues and was associated with the (Tumor Node Metastasis) TNM stage, suggesting that DJ‐1 may be a novel prognostic biomarker and potential therapeutic target in human CRC.
Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition.
- Xiaoyi Sun, Hua Yang, D. Teitelbaum
- MedicineAmerican Journal of Physiology - Gastrointestinal…
- 2008
Exogenous IL-10 administration in TPN mice significantly attenuated the TPN-associated decline in zonula occludens (ZO)-1, E-cadherin, and Occludin expression, as well as a loss of intestinal barrier function.
Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function.
- K. Nose, Hua Yang, D. Teitelbaum
- Medicine, BiologyJournal of Interferon and Cytokine Research
- 28 February 2010
Glutamine-supplemented TPN leads to a specific IEL-derived cytokine profile, which may account for the preservation of EBF; and such action may be due to a direct action of glutamine on the IEL.
Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition
- Hua Yang, R. Finaly, D. Teitelbaum
- Medicine, BiologyCritical Care Medicine
- 1 April 2003
Interferon-&ggr; appears to play an important role in the loss of the epithelial barrier function that is associated with total parenteral nutrition.
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