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Abstract(R)-ethyl-3-hydroxyglutarate with highly optical purity (≥99%) can be used as a novel precursor for synthesis of chiral side chain of rosuvastatin. In this study, a novel synthesis route of… (More)
Abstract Optically pure ethyl ( S )-3-hydroxyglutarate [( S )-3-EHG] is used as a key precursor for synthesis of a variety of pharmaceutically important compounds. In this work, we established an… (More)
A convenient ion-pair LC procedure was firstly established for rapid analysis of ethyl 3-hydroxyglutarate (3-EHG) in an enzymatic-hydrolysis mixture, and the detection limit was as low as 0.45 μmol… (More)