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Kisspeptins are a family of overlapping neuropeptides, encoded by the Kiss1 gene, that are required for activation and maintenance of the mammalian reproductive axis. Kisspeptins act within the hypothalamus to stimulate release of gonadotrophic releasing hormone and activation of the pituitary-gonadal axis. Robust model systems are required to dissect the(More)
Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (GPR54 also called KISS1R) are also expressed in the testes but a functional role in this tissue has not been confirmed. We examined(More)
PURPOSE We tested the viability of human limbal mesenchymal cells (LMCs) to support the expansion of human corneal epithelial stem/progenitor cells (LSCs). METHODS Human LMCs were isolated from sclerocorneal tissue using collagenase A. Primary limbal epithelial cells (LECs) in the form of single cell suspension or cell clusters were cocultured on a(More)
At puberty, the mammalian reproductive axis is activated by neuroendocrine events within the hypothalamus that initiate pulsatile secretion of gonadotropin releasing hormone (GnRH) to activate the pituitary/gonadal axis. Thus, puberty is critically dependent on the integrity of GnRH neuronal activity. Defects in the migration of GnRH neurons into the(More)
Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus.(More)
The association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk has been widely investigated, but remains controversial. We therefore undertook a comprehensive meta-analysis to provide a high-quality evaluation of this association. A literature search was performed among Pubmed, EMBASE and Chinese National Knowledge Infrastructure(More)
In this paper, a new identification method performed in the time domain based on the decentralized step-test is proposed for two inputs and two outputs (TITO) processes with significant interactions. In terms of parameter identification, the coupled closed-loop TITO system is decoupled to obtain four individual single open-loop systems with the same input(More)
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