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PURPOSE To efficiently and effectively recover the susceptibility-induced signal losses for functional MRI (fMRI) experiments. MATERIALS AND METHODS The signal losses near air/tissue interfaces at the ventral brain regions introduce difficulties in the neuroimaging studies concerned with brain functions such as memory, emotion, and olfaction processes.(More)
Trastuzumab is a successful rationally designed ERBB2-targeted therapy. However, about half of individuals with ERBB2-overexpressing breast cancer do not respond to trastuzumab-based therapies, owing to various resistance mechanisms. Clinically applicable regimens for overcoming trastuzumab resistance of different mechanisms are not yet available. We show(More)
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream signaling of phosphoinositide 3-kinase (PI3K), we investigated the role of PTEN and other components of the PI3K pathway in trastuzumab resistance. We analyzed the status of PTEN, p-AKT-Ser473, and(More)
Bloom filters are a randomized data structure for membership queries dating back to 1970. Bloom filters sometimes give erroneous answers to queries, called false positives. Bloom analyzed the probability of such erroneous answers, called the false-positive rate, and Bloom's analysis has appeared in many publications throughout the years. We show that(More)
Signatures of mass-independent isotope fractionation (MIF) are found in the oxygen ((16)O,(17)O,(18)O) and sulfur ((32)S, (33)S, (34)S, (36)S) isotope systems and serve as important tracers of past and present atmospheric processes. These unique isotope signatures signify the breakdown of the traditional theory of isotope fractionation, but the physical(More)
Although generalized T-cell activation is an important factor in chronic HIV disease pathogenesis, its role in primary infection remains poorly defined. To investigate the effect of immune activation on T-cell changes in subjects with early HIV infection, and to test the hypothesis that an immunologic activation "set point" is established early in the(More)
The ubiquitously expressed 14-3-3 proteins are involved in numerous important cellular functions. The loss of 14-3-3sigma is a common event in breast cancer; however, the role of other 14-3-3s in breast cancer is unclear. Recently, we found that 14-3-3zeta overexpression occurs in early stage breast diseases and contributes to transformation of human(More)
The algorithm of Liu and Nguyen [IEEE Microw. Guided Wave Lett. 8 (1) (1998) 18; SIAM J. Sci. Comput. 21 (1) (1999) 283] for nonuniform fast Fourier transform (NUFFT) has been extended to two dimensions to reconstruct images using spiral MRI. The new gridding method, called LS_NUFFT, minimizes the reconstruction approximation error in the Least Square sense(More)
Diffusion tensor imaging (DTI) has seen increased usage in clinical and basic science research in the past decade. By assessing the water diffusion anisotropy within biological tissues, e.g. brain, researchers can infer different fiber structures important for neural pathways. A typical DTI data set contains at least one base image and six(More)
We have co-amplified 17 Y-chromosomal STRs (including DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a,b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and Y GATA H4) for samples of 143 unrelated male individuals of Chinese Hui Ethnic Minority Group. We obtained allelic frequency distribution and haplotype diversity of 17(More)