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OBJECTIVES Brimonidine tartrate ophth, an alpha(2)-adrenergic agonist, is widely used as an antiglaucoma agent for lowering intraocular pressure. Recent studies suggest that brimonidine may be neuroprotective for retinal ganglion cells (RGCs) following optic nerve crush injury. Brain-derived neurotrophic factor (BDNF), a potent neuroprotective factor(More)
—A power and area efficient sensor interface consumes 6.4 mW from 1.2 V while occupying 5 mm 5 mm in 0.13 m CMOS. The interface offers simultaneous access to 96 channels of broadband neural data acquired from cortical microelectrodes as part of a head-mounted wireless recording system, enabling basic neuroscience as well as neuroprosthetics research.(More)
Polyploidization results in genome duplication and is an important step in evolution and speciation. The Malus genome confirmed that this genus was derived through auto-polyploidization, yet the genetic and meiotic mechanisms for polyploidization, particularly for aneuploidization, are unclear in this genus or other woody perennials. In fact the(More)
We focused this work on handling variation in facial appearance caused by 3D head pose. A pose normalization approach based on fitting active appearance models (AAM) on a given face image was investigated. Profile faces with different rotation angles in depth were warped into shape-free frontal view faces. Face recognition experiments were carried out on(More)
The use of high throughput screening (HTS) to identify lead compounds has greatly challenged conventional quantitative structure-activity relationship (QSAR) techniques that typically correlate structural variations in similar compounds with continuous changes in biological activity. A new QSAR-like methodology that can correlate less quantitative assay(More)
The mechanistic underpinnings of metastatic dormancy and reactivation are poorly understood. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-β ligands, induces dormant breast cancer cells to undergo reactivation in the lung. Mechanistic studies indicate that Coco exerts this effect by blocking lung-derived BMP ligands. Whereas(More)
Gait recognition based on pro-crustes shape analysis, " in Proc. Fusion of static and dynamic body biometrics for gait recognition, " IEEE Trans. Automatic extraction and description of human gait models for recognition purposes, " in Comput. " The gait identification challenge problem: Data sets and baseline algorithm , " in Proc. The human ID gait(More)
  • Ji-Song Guan, Zhen-Zhong Xu, Hua Gao, Shao-Qiu He, Guo-Qiang Ma, Tao Sun +10 others
  • 2005
Opioid and tachykinin systems are involved in modulation of pain transmission in the spinal cord. Regulation of surface opioid receptors on nociceptive afferents is critical for opioid analgesia. Plasma-membrane insertion of delta-opioid receptors (DORs) is induced by stimulus-triggered exocytosis of DOR-containing large dense-core vesicles (LDCVs), but how(More)