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- Qingyi Ma, Sheng Chen, Qin Hu, Hua Feng, John H Zhang, Jiping Tang
- Annals of neurology
- 2014
OBJECTIVE
The NLRP3 (NALP3, cryopyrin) inflammasome, a key component of the innate immune system, facilitates caspase-1 and interleukin (IL)-1β processing, which amplifies the inflammatory response.… (More)
- Hai-tao Zhu, Chen Bian, +6 authors Jiang-kai Lin
- Journal of Neuroinflammation
- 2013
Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator… (More)
- Yujie Chen, Yan Zhang, +6 authors John H Zhang
- Stroke
- 2015
BACKGROUND AND PURPOSE
Norrin and its receptor Frizzled-4 have important roles in the blood-brain barrier development. This study is to investigate a potential role and mechanism of Norrin/Frizzled-4… (More)
- Baosong Liu, Lijun Li, +9 authors Qi Wan
- Stroke
- 2010
BACKGROUND AND PURPOSE
Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke,… (More)
- Rong Hu, Haodong Sun, +9 authors Hua Feng
- Critical care medicine
- 2012
OBJECTIVE
What underlies the protection of estrogen against spinal cord injury remains largely unclear. Here, we investigated the expression pattern of a new estrogen receptor, G-protein coupled… (More)
- Jiuquan Zhang, Yanling Zhang, +5 authors Hua Feng
- Brain Research
- 2010
Brain-iron deposition has been proposed to play an important role in the pathophysiology of Parkinson's disease (PD). The aim of this study was to evaluate the feasibility of characterizing iron… (More)
- Shengli Hu, Hai-shui Luo, +10 authors Hua Feng
- Critical care medicine
- 2010
OBJECTIVE
Spinal cord injury results in loss of neurons, degeneration of axons, formation of glial scar, and severe functional impairment. Human umbilical cord mesenchymal stem cells can be induced… (More)
- Zhao Yang, Tianzhi Zhao, Yongjie Zou, John H Zhang, Hua Feng
- Immunology letters
- 2014
Much evidence demonstrates that microglia mediated neuroinflammation is an important contributor to the inflammatory injury in intracerebral hemorrhage (ICH). Therefore, the compounds that can… (More)
Manganese superoxide dismutase (MnSOD) is over-expressed in most brain tumours, and high MnSOD expression is associated with poor prognosis. The mechanisms still remain largely unknown. In the… (More)
- Xiaopei Cui, Xiangju Liu, Hua Feng, Shaohua Zhao, Haiqing Gao
- Biological & pharmaceutical bulletin
- 2012
Grape seed proanthocyanidin extracts (GSPE) belonging to polyphenols, possess various biological effects including anti-inflammation, anti-oxidant, anti-aging, anti-atherosclerosis, etc. GSPE is… (More)