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Zebrafish Dpr2 Inhibits Mesoderm Induction by Promoting Degradation of Nodal Receptors
It is reported that zebrafish dapper2 (dpr2) is expressed in mesoderm precursors during early embryogenesis and is positively regulated by Nodal signals and accelerates lysosomal degradation of these receptors.
Regulation of Nur77 expression by β‐catenin and its mitogenic effect in colon cancer cells
It is demonstrated that Nur77 acts to promote the growth and survival of colon cancer cells and serves as an important mediator of the Wnt/β‐catenin and AP‐1 signaling pathways.
The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling.
The cloned mouse ortholog of zebrafish Dapper2, mDpr2, is cloned and its function in regulating TGF-beta signaling activity is investigated, indicating that the function of Dpr2 as a negative regulator of the TGF/Nodal signal pathway is evolutionally conserved in fish and mammals.
Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.
Overexpression of RARgamma plays a role in the growth of HCC cells through nongenomic activation of the PI3K/Akt and NF-kappaB signaling pathways, and results show that levels of R ARgamma were significantly elevated in tumor tissues from a majority of human hepatocellular carcinoma (HCC) and in HCC cell lines.
Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77
It is demonstrated that β-catenin can be degraded by cytoplasmic Nur77 through their interaction and identified H-9 and ATE-i2-b4 as potent activators of the Nur77-mediated pathway for β- catenin degradation.
Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK.
The results demonstrate that the apoptotic effect of CCE9 depended on its induction of Nur77 expression, cytoplasmic localization, and mitochondrial targeting and reveal a profound role of p38α MAPK in regulating the Nur77-Bcl-2 apoptotic pathway through its modulation of Nur 77 expression, Bcl- 2 phosphorylation, and their interaction.
The evolutionally conserved activity of Dapper2 in antagonizing TGF‐ß signaling
The data indicate that the function of Dpr2 as a negative regulator of the TGF‐ß/Nodal signal pathway is evolutionally conserved, at least in part, in fish and mammals.