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BACKGROUND To investigate the effect of long-term smoking on the activity and mRNA expression of cytochrome P450 (CYP) enzymes. METHODS Sprague-Dawley rats were exposed to passive smoking 6 cigarettes per day for 180 days. A cocktail solution which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), chlorzoxazone (20 mg/kg) and midazolam (10 mg/kg)(More)
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