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PURPOSE Blood-retinal barrier [BRB] breakdown, characteristic of diabetic retinopathy (DR), is believed to depend on inflammation and apoptosis. Retinal inflammation is almost completely suppressed in the absence of TNFα, which is also associated with apoptosis. This study was conducted to determine the role of TNFα in these diabetic complications. (More)
The future of cellular radio ICs lies in the integration of an ever-increasing number of bands and channel bandwidths. Figure 21.2.1 shows the block diagram of our transceiver, together with the associated discrete front-end components. The transceiver supports 4 EDGE bands and 9 WCDMA bands (I-VI and VIII-X), while the radio can be configured to(More)
OBJECTIVE VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological angiogenesis and vascular leakage in ischemic(More)
Previously we have explained the abstract concept we call ‘aqueous computing’ and illustrated it with concrete wet lab results. Here, we explore the use of methylase enzymes to ‘write’ on double-stranded DNA molecules at sites where restriction enzymes will cut if, and only if, the sites have not previously been methylated. A site represents the bit zero(More)
Follicular lesions of the thyroid remain significant diagnostic challenges in surgical pathology and cytology. The diagnosis often requires considerable resources and ancillary tests including immunohistochemistry, molecular studies, and expert consultation. Visual analyses of nuclear morphological features, generally speaking, have not been helpful in(More)
Although blocking VEGF has a positive effect in wet age-related macular degeneration (AMD), the effect of blocking its receptors remains unclear. This was an investigation of the effect of VEGF receptor (VEGFR) 1 and/or 2 blockade on retinal microglia/macrophage infiltration in laser-induced choroidal neovascularization (CNV), a model of wet AMD. CNV(More)
Although much is known about the pathophysiological processes contributing to diabetic retinopathy (DR), the role of protective pathways has received less attention. The transcription factor nuclear factor erythroid-2-related factor 2 (also known as NFE2L2 or NRF2) is an important regulator of oxidative stress and also has anti-inflammatory effects. The(More)
Human tracking [1] based on computer vision, is a challenging and crucial problem in intelligent video surveillance [2] system. As is known to all, human motion [3] is usually non-linear and non-Gaussian, many prevalent frameworks are not appropriate, such as Kalman Filter [4], etc. Nevertheless, the Particle Filter [5][6][7][8] could still have good(More)
Real-time gaze tracking is a promising interaction technique for virtual environments. Immersive projection-based virtual reality systems such as the CAVE allow users a wide range of natural movements. Unfortunately, most head and eye movement measurement techniques are of limited use during free head and body motion. An improved head-eye tracking system is(More)
In order to achieve noise figure smaller than 1dB, the GNSS receivers require external LNA, which adds area, cost and current consumption. A 28nm CMOS sub-1dB NF 9mW GNSS receiver is presented, requiring no external components. This work takes advantage of symmetry in performance between NMOS and PMOS at 28nm node and demonstrates that low NF is possible on(More)