Hsun-Lun Huang

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A patch formulation of rivastigmine, an inhibitor of acetylcholinesterase and butyrylcholinesterase, is under development. The current objective was to evaluate the pharmacokinetic profile and patch adhesiveness following application at the upper back, chest, abdomen, thigh, and upper arm. In a single-dose, open-label, crossover study with 40 (42.5% men)(More)
INTRODUCTION Activation patterns during permanent atrial fibrillation (AF) in patients with organic heart diseases are unclear. METHODS AND RESULTS We studied six patients with permanent AF and organic heart diseases undergoing surgery. The duration of AF averaged 4.9+/-7.6 years. Computerized epicardial mappings of the right atrial (RA) free wall and the(More)
OBJECTIVES The rivastigmine transdermal patch is the first transdermal treatment for Alzheimer's disease (AD) and dementia associated with Parkinson's disease. The objective of this study was to evaluate the pharmacokinetics of rivastigmine following transdermal delivery by a patch versus oral delivery with conventional capsules in a population of AD(More)
AIMS Sotrastaurin is an immunosuppressant that reduces T-lymphocyte activation via protein kinase C inhibition. The effect of CYP3A4 inhibition by ketoconazole on the pharmacokinetics of sotrastaurin, a CYP3A4 substrate, was investigated. METHODS This was a two-period, single-sequence crossover study in 18 healthy subjects. They received a single 50 mg(More)
In this article 36 cases of recurrent oropharyngeal ulcers were differentiated according to the local condition of the oropharyngeal ulcerations, tongue pictures, pulse feeling and other signs and symptoms. The authors considered this disease as the deficiency syndrome accompanied with the excess syndrome. The three steps for treatment were: Treating the(More)
For conventional wireless transceiver architectures with software-defined radio (SDR) technology, the communication between microcontrollers, DSPs (digital signal processors), and memories are through public shared buses. As wireless standards change frequently, the demands of bus bandwidth increase. To avoid bus bottlenecks and to get better performance,(More)
Since 3D graphic applications have reached mobile devices and known a tremendous expansion, graphic processors' power consumption has become a major challenge in mobile SoC design. We propose a high-level hardware agnostic model endorsed by GPU energy consumption measurements under specific 3D graphic applications running. The modeling method comprises of(More)
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