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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

• Irene Noguera-Troise, Christopher Daly, +6 authors Gavin Thurston
• Nature
• 2006

Tumour growth requires accompanying expansion of the host vasculature, with tumour progression often correlated with vascular density. Vascular endothelial growth factor (VEGF) is the… (More)

Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway.

• Esther Latres, Ami R. Amini, +6 authors David J Glass
• The Journal of biological chemistry
• 2005

Skeletal muscle size is regulated by anabolic (hypertrophic) and catabolic (atrophic) processes. We first characterized molecular markers of both hypertrophy and atrophy and identified a small subset… (More)

DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.

• Elvira Olaso, Kazuo Ikeda, +4 authors Scott L Friedman
• The Journal of clinical investigation
• 2001

Type I collagen provokes activation of hepatic stellate cells during liver injury through mechanisms that have been unclear. Here, we tested the role of the discoidin domain tyrosine kinase receptor… (More)

Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.

• Elvira Olaso, J Labrador, +6 authors Scott L Friedman
• The Journal of biological chemistry
• 2002

Discoidin domain receptor 2 (DDR2) is a tyrosine kinase receptor expressed in mesenchymal tissues, the ligand of which is fibrillar collagen. We have compared DDR2 signaling in skin fibroblasts… (More)

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

• Nicholas Gale, Melissa G. Dominguez, +9 authors George D. Yancopoulos
• Proceedings of the National Academy of Sciences…
• 2004

Vascular development depends on the highly coordinated actions of a variety of angiogenic regulators, most of which apparently act downstream of vascular endothelial growth factor (VEGF). One… (More)

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

• Keith D Anderson, Li Pan, +16 authors Nicholas Gale
• Proceedings of the National Academy of Sciences…
• 2011

The vasculature of the CNS is structurally and functionally distinct from that of other organ systems and is particularly prone to developmental abnormalities and hemorrhage. Although other embryonic… (More)

Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).

• Christopher Daly, Vivian (Wai Chong) Wong, +8 authors John S. Rudge
• Genes & development
• 2004

Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely… (More)

Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.

• Kazuo Ikeda, L Wang, +9 authors Hsin C. Lin
• The Journal of biological chemistry
• 2002

Discoidin domain receptor 2 (DDR2) is an unusual receptor tyrosine kinase in that its ligand is fibrillar collagen rather than a growth factor-like peptide. We examined signal transduction pathways… (More)

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow.

• Ivan B. Lobov, Eunice Y. L. Cheung, +8 authors Stanley J. Wiegand
• Blood
• 2011

Blood vessel remodeling is crucial to the formation of the definitive vasculature, but little is known about the mechanisms controlling this process. We show that Delta-like ligand 4 (Dll4)/Notch… (More)

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

• Yurong Xin, Jinrang Kim, +9 authors Jesper Gromada
• Proceedings of the National Academy of Sciences…
• 2016

This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells. The system combines microfluidic technology and nanoliter-scale reactions. We… (More)

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