Hsei-Di Law

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Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigen-binding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from a(More)
For two decades, Th1 cells have been implicated in the pathogenesis of chronic inflammatory diseases. This notion has been challenged by the discovery of IL-23 and Th17 cells as key players in mouse inflammatory disease models. Furthermore, recent genome wide association studies have found a strong association between spondylarthropathy (SpA, a group of(More)