Hruda Nanda Mallick

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l-Glutamate is a multifunctional amino acid involved in taste perception, intermediary metabolism, and excitatory neurotransmission. In addition, recent studies have uncovered new roles for l-glutamate in gut-brain axis activation and energy homeostasis. l-Glutamate receptors and their cellular transduction molecules have recently been identified in gut(More)
The medial preoptic area plays an important role in the regulation of male sexual behavior in rats, and this area receives orexinergic inputs. The role of orexinergic inputs in the medial preoptic area in sexual behavior has not been studied, though they have been shown to play a role in some other physiological functions. In this study, the changes in male(More)
Adrenergic alpha 2 agonist (clonidine) and its antagonist (yohimbine) were locally applied to the medial preoptic area (mPOA), to find out the role of alpha 2 receptors at this brain region in the regulation of sleep-wakefulness. Clonidine produced arousal, whereas yohimbine induced sleep in freely moving animals. Behavioural arousal produced by clonidine(More)
Several studies have suggested that noradrenergic afferents to the medial preoptic area might be involved in hypnogenesis and in lowering the body temperature, and that the alpha1 adrenergic receptors might be mediating these responses. This study was undertaken to find out the changes in sleep-wakefulness and body temperature in rats, when these adrenergic(More)
Changes in sleep and body temperature in rats at ambient temperatures below and above the self-selected temperature zone, are lacking in literature. In this report, the temperature preferred by the rats was first assessed before studying the changes in their sleep and body temperature, when they were exposed to ambient temperatures ranging from 18 degrees C(More)
The effects of the destruction of the medial septal neurons (MS) with N-methyl-d-aspartic acid on sleep-wakefulness (S-W), body temperature (Tb), locomotor activity (LMA) and thermal preference were studied in male Wistar rats. When these rats were given a choice of three ambient temperatures (Tamb) of 24, 27 and 30 degrees C, they preferred 27 degrees C(More)
Brain temperatures (Tbr) of male Wistar rats were recorded at every 15 min interval for 24 h, prior to the destruction of the medial septal (MS) neurons with N-methyl-D-aspartic acid, and on the 7th, 14th and 21st days after the destruction. The capacity of the rats to regulate their body temperature under severe cold and heat was assessed by recording(More)
Alterations in sleep induced by chronic exposure to mild changes in ambient temperature (Ta) were studied in male Wistar rats with chronically implanted electrodes for recording electrooculogram (EOG), electroencephalogram (EEG) and electromyogram (EMG), and a thermocouple to record the brain temperature (Tbr). Changes in sleep-wakefulness (S-W) and Tbr on(More)
The effects of electrical stimulation to the septum on penile erections in rats were examined to clarify the mechanisms for regulation of erectile responses during different states of vigilance. Penile responses were assessed by changes in pressure in the corpus spongiosum of penis (CSP) and electromyography (EMG) of the bulbospongiosus (BS) muscle. In(More)
The study was aimed at investigating the possible involvement of noradrenergic mechanisms in the lateral septum (LS) for elaboration of male sexual behavior in rats. In this study, norepinephrine (NE), yohimbine (YOH), isoproterenol (ISOP), propranolol (PROP), saline (SAL) and dimethyl sulfoxide (DMSO) were injected bilaterally in the LS in six different(More)