Howraman Meteran

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BACKGROUND Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality and is associated with several systemic diseases, such as type 2 diabetes. It has been suggested that comorbidity between COPD and type 2 diabetes is due to shared genetic factors. AIM To examine the relationship between type 2 diabetes and chronic(More)
It is well known that smoking is a major risk factor for lung disease and respiratory symptoms. We examined the association between smoking and the risk of chronic bronchitis in a large twin sample. In a population-based questionnaire study of 13,649 twins, aged 50–71 years, from the Danish Twin Registry, we identified 1,146 twin pairs, discordant for a(More)
BACKGROUND Smoking is a major risk factor for lung diseases and lower respiratory symptoms, but since not all smokers develop chronic bronchitis and since chronic bronchitis is also diagnosed in never-smokers, it has been suggested that some individuals are more susceptible to develop chronic bronchitis due to genetics. OBJECTIVE To study the relative(More)
BACKGROUND Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise(More)
BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder associated with lower airway disease. However, only few studies of CRSwNP from outside secondary/tertiary care centres have been published. We recently reported an asthma frequency of 44% and 65% in primary and secondary care patients respectively. Therefore, we(More)
AIM To provide a general overview of the current biological treatments and discuss their potential anti-asthmatic effects. DATA SOURCES We reviewed articles in PubMed found using the search words "Asthma/therapy AND antibodies, monoclonal/therapeutic use AND cytokines." STUDY SELECTIONS Only articles published in English since 2000 were considered. The(More)
The fixed ratio criterion of forced expiratory volume in 1 s/forced vital capacity <0.70 for diagnosing airway obstruction may overdiagnose the condition, particularly in the elderly, so the lower limit of normal (LLN) is recommended as the most appropriate criterion. Our aim was to compare LLN versus fixed ratio on the prevalence of chronic obstructive(More)
INTRODUCTION Asthma is a common respiratory disease characterized by airway inflammation, bronchoconstriction and airway hyperresponsiveness and symptoms such as coughing, wheezing, shortness of breath and chest tightness. Allergic rhinitis is a common comorbidity in asthma and glucocorticoids are the key stone in the treatment of both diseases. Mometasone(More)
DEAR EDITOR, We read with interest the report by Fang et al. of the relationship between psoriasis and asthma in a large retrospective case–control study from Taiwan. The study found a 1 38-fold increased risk of asthma among patients with psoriasis, with an increasing risk according to higher age of the patients. However, although adjustment for age, sex(More)
BACKGROUND Allergic reactions to airborne allergens may have important consequences for affected individuals and are believed to be unstable through life, although evidence from longitudinal studies is limited. OBJECTIVE To assess changes in skin prick reactivity during 20 years in a random population sample of children and adolescents in relation to(More)