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Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

• Gilbert Di Paolo, Howard S. Moskowitz, +7 authors Pietro De Camilli
• Nature
• 2004

Phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) has an important function in cell regulation both as a precursor of second messenger molecules and by means of its direct interactions with… (More)

Highly cooperative control of endocytosis by clathrin.

• Howard S. Moskowitz, Charles T. Yokoyama, Timothy A Ryan
• Molecular biology of the cell
• 2005

Clathrin assembles into a dynamic two-dimensional lattice on the plasma membrane where it plays a critical role in endocytosis. To probe the regulation of this process, we used siRNA against… (More)

Targeted chemical disruption of clathrin function in living cells.

• Howard S. Moskowitz, John M Heuser, Timothy E McGraw, Timothy A Ryan
• Molecular biology of the cell
• 2003

The accurate assignment of molecular roles in membrane traffic is frequently complicated by the lack of specific inhibitors that can work on rapid time scales. Such inhibition schemes would… (More)

Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing.

• Ying-Xian Pan, Jin Xu, Elizabeth A. Bolan, Howard S. Moskowitz, Mingming Xu, Gavril W Pasternak
• Molecular pharmacology
• 2005

The rat mu-opioid receptor clone in which novel exon 5 was found in the place of exon 4 (MOR-1B) was one of the first MOR-1 variants described. We now have identified the mouse homolog of the rat… (More)

Expression of Panulirus shaker potassium channel splice variants.

• Moonkyung Mark Kim, Deborah J. Baro, +4 authors Ronald M. Harris-Warrick
• Receptors & channels
• 1998

In Drosophila shaker voltage-dependent potassium channels, alternative splicing at the amino and carboxy termini produces currents with different electrophysiological characteristics. We have cloned… (More)

Epithelioid hemangioendothelioma of the middle ear in a child.

• Howard S. Moskowitz, Ronald Jaffe, Barry E. Hirsch
• American journal of otolaryngology
• 2011

The differential diagnosis of middle ear masses encompasses a wide variety of pathologic conditions. In this report, we describe the case of a 6-year-old girl who presented with facial nerve weakness… (More)

Alternative splicing in the pore-forming region of shaker potassium channels.

• Moonkyung Mark Kim, Deborah J. Baro, +6 authors Ronald M. Harris-Warrick
• The Journal of neuroscience : the official…
• 1997

We have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 5' and 3' ends of the… (More)

Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer.

• Howard S. Moskowitz, W. E. Gooding, +5 authors Robert L Ferris
• Oral oncology
• 2012

OBJECTIVE Targeting the epidermal growth factor receptor (EGFR) using the tyrosine kinase inhibitor (TKI) erlotinib has demonstrated activity in aerodigestive tract malignancies. Co-targeting of the… (More)

Synaptic calcium regulation in hair cells of the chicken basilar papilla.

• Gi Jung Im, Howard S. Moskowitz, Mohammed Lehar, Hakim Hiel, Paul Albert Fuchs
• The Journal of neuroscience : the official…
• 2014

Cholinergic inhibition of hair cells occurs by activation of calcium-dependent potassium channels. A near-membrane postsynaptic cistern has been proposed to serve as a store from which calcium is… (More)

Temporal bone involvement in Hand-Schuller-Christian disease.

• David J Mener, Howard S. Moskowitz, Charles M. Stewart
• Otology & neurotology : official publication of…
• 2015

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