Howard R Soule

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The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal(More)
INTRODUCTION The Prouts Neck Meetings on Prostate Cancer began in 1985 through the efforts of the Organ Systems Branch of the National Cancer Institute to stimulate new research and focused around specific questions in prostate tumorigenesis and therapy. METHODS These meetings were think tanks, composed of around 75 individuals, and divided equally(More)
PCa at all stages. Of significant clinical concern are neuroendocrine PCa subtypes including SCNC, which arise in response to treatments with androgen deprivation therapies (ADT) and are becoming more prevalent with the second generation ADT medications enzalutamide and abiraterone acetate. Lipianskaya et al. 1 further review studies identifying molecular(More)
Molecular changes associated with breast cancer progression were characterized using the MCF-10F cell series. MCF-10F was established from fibrous mastectomy tissue of a patient without detectable cancer. In vitro treatment of MCF-10F cells with benzo(a)pyrene resulted in a transformed subclone MCF-10F-BP1 (BP1). Transfection of clone BP1 with T24-Hras(More)
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