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Membrane protein plays an important role in some biochemical process such as signal transduction, transmembrane transport, etc. Membrane proteins are usually classified into five types [Chou, K.C., Elrod, D.W., 1999. Prediction of membrane protein types and subcellular locations. Proteins: Struct. Funct. Genet. 34, 137-153] or six types [Chou, K.C., Cai,(More)
—In this paper, a new dance training system based on the motion capture and virtual reality (VR) technologies is proposed. Our system is inspired by the traditional way to learn new movements—imitating the teacher's movements and listening to the teacher's feedback. A prototype of our proposed system is implemented, in which a student can imitate the motion(More)
Anthrax lethal toxin (LT), a virulence factor secreted by Bacillus anthracis, is selectively toxic to human melanomas with the BRAF V600E activating mutation because of its proteolytic activities toward the mitogen-activated protein kinase kinases (MEKs). To develop LT variants with lower in vivo toxicity and high tumor specificity, and therefore greater(More)
Kaposi's sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-8/KS-associated herpesvirus [KSHV]) infection, is the most common AIDS-associated malignancy. Clinical management of KS has proven to be challenging because of its prevalence in immunosuppressed patients and its unique vascular and inflammatory nature that is sustained(More)
Mutations in capillary morphogenesis gene 2 (CMG2), one of the two closely related proteins that act as anthrax toxin receptors, cause two rare human autosomal recessive conditions, juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH). Here we demonstrate that CMG2 proteins with certain JHF- and ISH-associated single amino acid(More)
AIMS Kaposi's sarcoma (KS), caused by the Kaposi's sarcoma herpesvirus (KSHV), is an AIDS-associated cancer characterized by angiogenesis and proliferation of spindle cells. Rac1-activated reactive oxygen species (ROS) production has been implicated in KS tumorigenesis. We used an animal model of KSHV-induced Kaposi's sarcomagenesis (mECK36) to study the(More)
Evaluating the similarity of motions is useful for motion retrieval, motion blending, and performance analysis of dancers and athletes. Euclidean distance between corresponding joints has been widely adopted in measuring similarity of postures and hence motions. However, such a measure does not necessarily conform to the human perception of motion(More)
An efficient retrieval mechanism is essential to search for a particular motion from a large corpus. This has proven to be a challenging task as human motion is high dimensional in both spatial and temporal domains. Besides, semantically similar motions are not necessary numerically similar because of the speed variations. In this paper, we propose a(More)
We have implemented an interactive dancing game using optical 3D motion capture technology. We propose a <i>Progressive Block Matching</i> algorithm to recognize the dance moves performed by the player in real-time. This makes a virtual partner be able to recognize and respond to the player's movement without a noticeable delay. The completion progress of a(More)
Finding repetitive patterns is important to many applications such as bioinformatics, finance and speech processing, etc. Repetitive patterns can be either cyclic or acyclic such that the patterns are continuous and distributed respectively. In this paper, we are going to find repetitive patterns in a given motion signal without prior knowledge about the(More)