Howard L. Houghton

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Cefotetan disodium has been given by zero order intravenous infusion at 75.8 mg/h to four healthy male volunteers over a 24-h period. Plasma concentrations rose until by 12 hs a mean steady state value of 37.5 mg/l was attained. In an additional four volunteers a loading dose of 0.5 g cefotetan was given immediately prior to a similar infusion. In these(More)
Cefotetan, a third generation cephalosporin, in doses of 0.25, 0.5, 1.0 and 2.0 g was administered intravenously as the disodium salt to ten healthy male Caucasian volunteers and its pharmacokinetics and tolerance determined. The elimination half-life was 3.3 h. The drug was 88% plasma protein bound and 67% was recovered unchanged in the urine. HPLC and(More)
Visit nonadherence, that is, "no shows," in psychiatry costs the US healthcare $100 billion every year. Nonadherent visits undermine healthcare quality improvement efforts and erode patients' health. Previous research has focused on patient demographics or on redundant scheduling, rather than on the actual structure of visit nonadherence. Drawing on a(More)
Concept mapping is a powerful research tool using visual representation to expose the complementary impact and synergy of factors affecting a specific process. This article outlines an example, in the domain of mental health, of concept mapping applied to the specific issue of readmissions or recidivism of mental health patients. Concept mapping is used to(More)
Cefotetan excretion was studied in 17 patients undergoing biliary or pancreatic surgery. The antibiotic was detected in bile taken from the common bile duct within 15 min of a 1 g iv bolus and therapeutic plasma levels were found up to 10 h after administration. Even higher concentrations of cefotetan were measured in the bile from functioning gall(More)
Technology cannot be effectively used to drive improvements in health care quality and health care cost reduction until significantly more healthcare visits are attended. Visit attendance is often perceived as an intractable problem. This formative study identified and analyzed a set of visit adherence determinants to delineate a structure of adherence. The(More)
Cefotetan, a third-generation cephalosporin, is extremely well tolerated by healthy Caucasian volunteers when given by intramuscular injection. It gives rise to prolonged high plasma antibiotic concentrations. Lignocaine (0.5%), when used as a diluent, had no effect on the pharmacokinetic parameters of cefotetan. Two grams of cefotetan given as the disodium(More)
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