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BACKGROUND Late-onset Alzheimer disease (LOAD) is a clinically heterogeneous complex disease defined by progressively disabling cognitive impairment. Psychotic symptoms which affect approximately one-half of LOAD subjects have been associated with more rapid cognitive decline. However, the variety of cognitive trajectories in LOAD, and their correlates,(More)
A large body of evidence supports the importance of focused attention for encoding and task performance. Yet young children with immature regulation of focused attention are often placed in elementary-school classrooms containing many displays that are not relevant to ongoing instruction. We investigated whether such displays can affect children's ability(More)
OBJECTIVE The trajectory of cognitive decline in patients with late-onset Alzheimer's disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in elderly individuals at risk for the disease. METHOD The authors developed a(More)
Family data teamed with the transmission/disequilibrium test (TDT), which simultaneously evaluates linkage and association, is a powerful means of detecting disease-liability alleles. To increase the information provided by the test, various researchers have proposed TDT-based methods for haplotype transmission. Haplotypes indeed produce more-definitive(More)
BACKGROUND Associations between schizophrenia (SCZ) and polymorphisms at the regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18). Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles. METHODS In an effort to resolve the role(More)
Association studies, both family-based and population-based, can be powerful means of detecting disease-liability alleles. To increase the information of the test, various researchers have proposed targeting haplotypes. The larger number of haplotypes, however, relative to alleles at individual loci, could decrease power because of the additional degrees of(More)
OBJECTIVE Seven measures of neonatal EEG-sleep behavior were evaluated using multivariate analyses to ascertain if physiologic differences exist between healthy full- and preterm cohorts. METHODS A total of 381 24-channel EEG-sleep studies were analyzed, including 125 recordings on 50 healthy fullterm and 256 recordings on 59 asymptomatic preterm infants(More)
ii Preface This book is intended as required reading material for my course, Experimental Design for the Behavioral and Social Sciences, a second level statistics course for undergraduate students in the College of Humanities and Social Sciences at Carnegie Mellon University. This course is also cross-listed as a graduate level course for Masters and PhD(More)
Speech categories are defined by multiple acoustic dimensions, and listeners give differential weighting to dimensions in phonetic categorization. The informativeness (predictive strength) of dimensions for categorization is considered an important factor in determining perceptual weighting. However, it is unknown how the perceptual system weighs acoustic(More)