Howard D. Sesso

Learn More
CONTEXT Physical inactivity and body mass index (BMI) are established independent risk factors in the development of type 2 diabetes; however, their comparative importance and joint relationship with diabetes are unclear. OBJECTIVE To examine the relative contributions and joint association of physical activity and BMI with diabetes. DESIGN, SETTING,(More)
BACKGROUND Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear. METHODS Among men with prostate cancer in the prospective Physicians' Health and Health Professionals Follow-Up Studies, we identified rearrangement status by(More)
BACKGROUND Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited. OBJECTIVE We aimed to determine whether baseline intake of whole or refined grains is associated with subsequent development of hypertension. DESIGN We conducted a prospective cohort study in(More)
BACKGROUND Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear. METHODS AND RESULTS We searched MEDLINE and EMBASE from 1966 through February 2012 for prospective studies that assessed the association of(More)
OBJECTIVES This study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality. BACKGROUND Previous studies suggest a J-shaped relation between alcohol and total mortality in men. A decrease in cardiovascular disease (CVD) mortality without a significant increase in other causes of mortality may explain the(More)
OBJECTIVES This study was designed to examine the hypothesis that higher intake of dietary fiber is inversely related to the risk of cardiovascular disease (CVD) and myocardial infarction (MI) in a large prospective cohort of women. BACKGROUND Although dietary fiber has been suggested to reduce the risk of coronary disease, few prospective studies have(More)
CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address this relationship. No previous trial in men at(More)
BACKGROUND Despite emerging evidence of the role of flavonoids in cardiovascular disease (CVD) prevention, the association remains unclear. OBJECTIVE We examined whether flavonoids and selected flavonols and flavones or their food sources are associated with CVD risk. DESIGN Women (n = 38 445) free of CVD and cancer participated in a prospective study(More)
IMPORTANCE Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking.(More)
Some studies have suggested that diabetes mellitus may decrease the risk of prostate cancer because of lower insulin levels. To further investigate the relation between diabetes and prostate cancer, a nested case-control study was conducted within the US Physicians' Health Study. Cases (n = 1,110) had been diagnosed with prostate cancer, confirmed on(More)