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- C. V. Weiss Brennan, Roel G W Verhaak, +55 authors Lynda Chin
- Cell
- 2013
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated… (More)
- Houtan Noushmehr, Daniel J. Weisenberger, +24 authors Kenneth D. Aldape
- Cancer cell
- 2010
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted… (More)
- Daniel J. Brat, Roel G. W. Verhaak, +304 authors Jianan Zhang
- The New England journal of medicine
- 2015
BACKGROUND
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that… (More)
- Toshinori Hinoue, Daniel J. Weisenberger, +9 authors Peter W. Laird
- Genome research
- 2012
Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are characterized by distinct genetic and epigenetic alterations. Here we performed comprehensive genome-scale DNA… (More)
- Benjamin P. Berman, Daniel J. Weisenberger, +9 authors Peter W. Laird
- Nature Genetics
- 2011
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale studies have yielded important… (More)
- Michele Ceccarelli, Floris P. Barthel, +43 authors Roel G W Verhaak
- Cell
- 2016
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes… (More)
- Andrew E. Teschendorff, Usha Menon, +18 authors Martin Widschwendter
- Genome research
- 2010
Polycomb group proteins (PCGs) are involved in repression of genes that are required for stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) are 12-fold more… (More)
- Antonio Colaprico, Tiago Campos Silva, +10 authors Houtan Noushmehr
- Nucleic acids research
- 2016
The Cancer Genome Atlas (TCGA) research network has made public a large collection of clinical and molecular phenotypes of more than 10 000 tumor patients across 33 different tumor types. Using this… (More)
- Loredana G Farilla, Angela Bulotta, +7 authors Riccardo Perfetti
- Endocrinology
- 2003
The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell mass, and inhibit beta-cell… (More)
- Paul D P Pharoah, Ya Yu Tsai, +165 authors Thomas A. Sellers
- Nature Genetics
- 2013
Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled… (More)