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Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
RET protein functions as a receptor-type tyrosine kinase and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the promoter plays anExpand
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Highly Efficient Production of Soluble Proteins from Insoluble Inclusion Bodies by a Two-Step-Denaturing and Refolding Method
The production of recombinant proteins in a large scale is important for protein functional and structural studies, particularly by using Escherichia coli over-expression systems; however,Expand
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Comparison of metabolites produced in vitro and in vivo by Photorhabdus luminescens ,a bacterial symbiont of the entomopathogenic nematode Heterorhabditis megidis
The types of metabolites produced by Photorhabdus luminescens C9 when it is introduced by Heterorhabditis megidis 90 into Galleria mellonella larvae are different from those produced in tryptic soyExpand
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Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex.
FR-008/candicidin is a heptaene macrolide with established antifungal activity, produced by Streptomyces sp. FR-008 as a complex mixture of compounds. Here, six components (FR-008-I to -VI) of theExpand
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Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea. TheirExpand
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Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on na,K-atpase from the okinawa sea sponge sp.1)
Abstract Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids having inhibitory effects on enzymic reactions of Na,K-ATPase, have been isolated from the orange colored Okinawan sea sponge AgelasExpand
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BmP09, a “Long Chain” Scorpion Peptide Blocker of BK Channels*
A novel “long chain” toxin BmP09 has been purified and characterized from the venom of the Chinese scorpion Buthus martensi Karsch. The toxin BmP09 is composed of 66 amino acid residues, includingExpand
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Five new Ocotillone-type saponins from Gynostemma pentaphyllum.
Five new ocotillone-type saponins, gynosides A-E (1-5), along with 10 known dammarane-type saponins, were isolated from the aerial parts of Gynostemma pentaphyllum. The structures of these newExpand
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Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification
Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification
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Rhabdastrellic acid-A, a novel triterpenoid from the marine sponge Rhabdastrella globostellata
A new isomalabaricane triterpenoid, rhabdastrellic acid-A (1), was isolated from the sponge Rhabdastrella globostellata (Carter) collected from the South China Sea near Hainan Island, People'sExpand
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