Hougelle Simplicio

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BACKGROUND Restoration of nerve continuity and effective maintenance of coaptation are considered fundamental principles of end-to-end peripheral nerve repair. OBJECTIVE To evaluate the influence of the number of stitches on axonal regeneration and collagen production after neurorrhaphy. METHODS Thirty male Wistar rats were equally divided into 3 groups(More)
We report a case of a 26-year-old man who presented a lower motor neuron syndrome due to hyperparathyroidism. Electromyography showed neurogenic features with normal nerve conduction studies. Hypercalcemia led to the discovery of a primary hyperparathyroidism with gland hyperplasia. Following parathyroid surgery there was recovery of the neurological(More)
Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method--epidural spinal cord stimulation (SCS)--has been suggested as an alternative approach for symptomatic treatment(More)
Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months.(More)
Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements(More)
Excitotoxicity is the major component in neuropathological conditions, related to harmful action of imbalanced concentrations of glutamate and its agonists in the nervous tissue, ultimately resulting in cell death. In the present study, we evaluated the effects of an acute striatal lesion induced by a focal N-methyl-D-aspartate (NMDA) microinjection on the(More)
I — Proposers — Maria Adelia Albano de Aratanha has a BSc. in Electrical Engineering, and a Dipl.-Ing in Biomedical Engineering. Works in the field of Brain Machine Interface (BMI) and virtual reality. — Hougelle Simplício has a MB in Medicine, and a PhD. in Neurology. Has experience on functional neurosurgery and neuromodulation(More)
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