- Full text PDF available (1)
IL-6 and downstream JAK-dependent signaling pathways have critical roles in the pathophysiology of multiple myeloma (MM). We investigated the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK signal transduction and its biological consequences on the human myeloma-derived cell lines U266 and Kms.11. At low micromolar concentrations,… (More)
The multifunctional RNA-binding protein CUGBP1 regulates multiple aspects of nuclear and cytoplasmic messenger RNA (mRNA) processing, including splicing, stabilization, and translation of mRNAs. Previous studies have shown that CUGBP1 is overexpressed in non-small-cell lung cancer (NSCLC) tissues, but the pathological functions of CUGBP1 in tumorigenesis… (More)
Most existing pedestrian detection methods always focus on improving detect accuracy of single pedestrian detection, but in this paper we focus on detect crowded pedestrians and recognizing adjacent or overlapped pedestrian exactly. We pro-pose a dissimilarity model to represent difference between adjacent pedestrians by utilizing relative spatial… (More)
A quantitative description of membrane current and its application to conduction and excitation in nerve. 17 Hänggi P. Stochastic resonance in biology-how noise can enhance detection of weak signals and help improve biological information processing.