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IL-6 and downstream JAK-dependent signaling pathways have critical roles in the pathophysiology of multiple myeloma (MM). We investigated the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK signal transduction and its biological consequences on the human myeloma-derived cell lines U266 and Kms.11. At low micromolar concentrations,(More)
The multifunctional RNA-binding protein CUGBP1 regulates multiple aspects of nuclear and cytoplasmic messenger RNA (mRNA) processing, including splicing, stabilization, and translation of mRNAs. Previous studies have shown that CUGBP1 is overexpressed in non-small-cell lung cancer (NSCLC) tissues, but the pathological functions of CUGBP1 in tumorigenesis(More)
  • Wang Zhiwei, Jiang Yuan, +4 authors Duan Yongjian
  • 2017
BACKGROUND The aim of this study was to evaluate the diagnostic value of Ventana immunohistochemistry (IHC) assay for anaplastic lymphoma kinase (ALK) gene rearrangement screening in patients with non-small cell lung cancer (NSCLC). METHODS Open published studies that reported the diagnostic performance of Ventana IHC assay for ALK gene rearrangement(More)
Most existing pedestrian detection methods always focus on improving detect accuracy of single pedestrian detection, but in this paper we focus on detect crowded pedestrians and recognizing adjacent or overlapped pedestrian exactly. We pro-pose a dissimilarity model to represent difference between adjacent pedestrians by utilizing relative spatial(More)
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