Hosuk Sean Lee

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Glial cells are an integral part of functional communication in the brain. Here we show that astrocytes contribute to the fast dynamics of neural circuits that underlie normal cognitive behaviors. In particular, we found that the selective expression of tetanus neurotoxin (TeNT) in astrocytes significantly reduced the duration of carbachol-induced gamma(More)
The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the ‘seed sequence’ and these(More)
Histone deacetylases (HDACs) and their inhibitors affect the integrity of blood–brain barrier (BBB) which plays an important role in pathological conditions of the central nervous system (CNS). In this study, expression of HDACs was examined in bEnd.3 endothelial cells subjected to oxygen and glucose deprivation (OGD)–reperfusion injury. Expression of(More)
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