Hossein Shayan

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We have tested the hypothesis that functional differences between synapses are associated with ultrastructure in cultured cortical neurons. Using Ca(2+) imaging, we measured NMDA receptor-mediated miniature synaptic calcium transients attributed to the spontaneous release of single transmitter quanta. After imaging, the identified neurons were processed for(More)
Hyperphosphorylation of the microtubule-associated protein tau is a characteristic of Alzheimer brain tissue. Recent in vitro data suggest that mitogen-activated protein kinase (MAPK), a proline-directed protein kinase, phosphorylates the sites on tau common to Alzheimer's disease. Using an okadaic acid-induced tau hyperphosphorylation model, we have tested(More)
Current electrophysiological and imaging methods have begun to target the subcellular structure and function of single CNS neurons. Although physiological imaging methods now permit the resolution of activity of single presynaptic and postsynaptic elements, it has not been possible to unequivocally examine the array of proteins expressed at these same(More)
A 51-year-old woman with a peritoneovenous shunt for refractory ascites presented with three months of increasing fatigue, exertional dyspnea, night sweats and positive blood cultures. Imaging revealed multiple pulmonary emboli. Transthoracic  chocardiography demonstrated moderate tricuspid regurgitation and a large pedunculated right atrial mass(More)
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