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  • Gary James Grover, Karnail S. Atwal, +4 authors David William Green
  • Biology, Medicine
  • American journal of physiology. Heart and…
  • 2004 (First Publication: 1 October 2004)
  • Mitochondrial F(1)F(0)-ATPase normally synthesizes ATP in the heart, but under ischemic conditions this enzyme paradoxically causes ATP hydrolysis. Nonselective inhibitors of this enzyme (aurovertin,Continue Reading
  • Tracy Mitchell, Ginger Chao, +15 authors Rex A. Parker
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2014 (First Publication: 1 August 2014)
  • Proprotein convertase subtilisin kexin-9 (PCSK9) is an important pharmacological target for decreasing low-density lipoprotein (LDL) in cardiovascular disease, although seemingly inaccessible toContinue Reading
  • Karnail S. Atwal, Paulina Wang, +6 authors Gary James Grover
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2004 (First Publication: 1 February 2004)
  • In this paper we show that 4-aryl-CH2-imidazole-substituted benzopyran compounds with 3S,4R-stereochemistry are cardioprotective by inhibiting the F1F0 mitochondrial ATP hydrolase. Compounds (e.g.,Continue Reading
  • Natesan Murugesan, Zhengxiang Gu, +14 authors John Eugene Macor
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005
  • In a previous report we demonstrated that merging together key structural elements present in an AT(1) receptor antagonist (1, irbesartan) with key structural elements in a biphenylsulfonamide ET(A)Continue Reading
  • Jun Li, Lawrence J. Kennedy, +44 authors Joseph A. Tino
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2010 (First Publication: 8 April 2010)
  • An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for humanContinue Reading
  • Mark C. Kowala, Natesan Murugesan, +21 authors John Eugene Macor
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2004 (First Publication: 1 April 2004)
  • Angiotensin II and endothelin-1 activate their respective AT(1) and ET(A) receptors on vascular smooth muscle cells, producing vasoconstriction, and both peptides are implicated in the pathogenesisContinue Reading