Hoshimi Kawaguchi

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BACKGROUND Although patients with systemic lupus erythematosus (SLE) may experience various gastrointestinal disorders, SLE and Crohn's disease (CD) rarely coexist. The diseases may have gastrointestinal (GI) manifestations, laboratory results, and radiographic findings that appear similar and consequently differentiating between GI involvement in CD and in(More)
In a previous paper1) we reported the synthesis and activity of 4'-deoxykanamycin A and showed that some strains of Pseudomonas aeru-ginosa and the aminoglycoside-resistant organisms which produced aminoglycoside-3'-phospho-transferase II were inhibited by 4'-deoxykana-mycin A. Recently, a new type of aminoglycoside inactivation has been disclosed in(More)
Structures of the new aminocyclitol antibiotics, inosamycins A, B, C, D and E, have been determined by a combination of chemical degradation and spectroscopic studies. They are structurally related to neomycin, paromomycin and ribostamycin but differ in that all the inosamycin components contain 2-deoxy-scyllo-inosamine in place of 2-deoxystreptamine in the(More)
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