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BACKGROUND & OBJECTIVES Group A streptococci (GAS) and human isolates of group C streptococci (GCS) have the stable capacity to produce the plasminogen activator streptokinase, albeit with varying efficiency. This property is subject to control by two two-component regulatory systems, FasCAX and CovRS, which act as activator and repressor, respectively. The… (More)
The most important problem in current therapy of childhood acute lymphoblastic leukemia (ALL) is a failure in over one-half of patients. We were unable to increase the failure-free survival of children with high risk ALL by a ten-drug regimen (modified LSA 2 L 2) above 30% at 6 years .