Hope Walker

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Children reared in unfavorable socioeconomic circumstances show increased susceptibility to the chronic diseases of aging when they reach the fifth and sixth decades of life. One mechanistic hypothesis for this phenomenon suggests that social adversity in early life programs biological systems in a manner that persists across decades and thereby accentuates(More)
Estrogen has well known effects on sexual behavior, however the role of the estrogen receptors (ER) alpha and beta on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERalpha and beta on sexual behaviors in the adult female rat. Subtype selective ER agonists, propyl-pyrazole triol (PPT;(More)
  • H A Walker
  • 1977
Dermatolglyphic patterns of autistic children were compared to those of control subjects matched socioeconomically and by age and sex. Analysis of dermal ridge patterns and ridge counts resulted in significant differences between the 78 autistic and 78 normal children. Differences from normal expectation in the autistic children were most apparent in the(More)
OBJECTIVE This study examined associations of asthma management-related beliefs and behaviors with immune markers and clinical outcomes in a sample of 66 children with asthma (ages 9-18 years). METHODS Children and parents were interviewed about asthma management beliefs and behaviors. Immune measures included stimulated production of cytokines implicated(More)
Attached please find a copy of the subject audit report. The primary objective was to review the Commission's implementation of GPRA. This encompassed reviewing documents, conducting interviews, and evaluating the framework of the strategic plan. The auditors determined that, while the Commission has made significant strides in meeting GPRA requirements, a(More)
Catechol-O-Methyltransferase (COMT) activity was studied in three groups of institutionalized children: (1) a group of schizophrenic children; (2) a heterogeneous group of chronic psychotic children characterized by severe symptomatology and onset before 5 years of age; (3) a group of acting-out but nonpsychotic children. Erythrocyte COMT activity was found(More)
The possible mechanisms that underlie symptom formation in childhood schizophrenia are discussed. A body of research evidence has been reviewed in which dissociation in relation to information processing was examined for its possible consequence in the formation and expression of symptomatology. Schizophrenic children have been found to exhibit dissociation(More)
This study compares concept usage and categorizing behavior among schizophrenic, normal, and brain-damaged children. Two sets of tasks were administered to each subject, the child being required to match an index object with one of a group of three choice objects. On the first task, the choice objects were related to the index object by class, function, or(More)