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Children reared in unfavorable socioeconomic circumstances show increased susceptibility to the chronic diseases of aging when they reach the fifth and sixth decades of life. One mechanistic hypothesis for this phenomenon suggests that social adversity in early life programs biological systems in a manner that persists across decades and thereby accentuates(More)
BACKGROUND Although social environment variables such as socioeconomic status (SES) have been linked to childhood asthma, little is known about the psychobiological mechanisms underlying this relationship. OBJECTIVES The goal of this study was to investigate relationships among SES, psychological stress, and immune processes implicated in asthma. (More)
OBJECTIVES Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. This study tested whether the social environment could get "under the skin" to alter genomic activity in(More)
Estrogen has well known effects on sexual behavior, however the role of the estrogen receptors (ER) alpha and beta on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERalpha and beta on sexual behaviors in the adult female rat. Subtype selective ER agonists, propyl-pyrazole triol (PPT;(More)
  • H A Walker
  • 1977
Children diagnosed as autistic were matched by age and sex with 74 control subjects and examined for presence of minor physical anomalies. Of the 16 anomalies scored, autistic children demonstrated a significant accumulation greater than the number exhibited by normal children. Three of the stigmata--low seating of ears, hypertelorism, and syndactylia--were(More)
This study examined longitudinal associations of asthma management-related beliefs and behaviors with changes in asthma-relevant biological markers in a sample of 43 children with asthma. Children (M age = 12.4, 75% male) and parents were interviewed about asthma management beliefs and behaviors. Asthma outcomes included lung function (FEV1%), eosinophil(More)
  • H A Walker
  • 1977
Dermatolglyphic patterns of autistic children were compared to those of control subjects matched socioeconomically and by age and sex. Analysis of dermal ridge patterns and ridge counts resulted in significant differences between the 78 autistic and 78 normal children. Differences from normal expectation in the autistic children were most apparent in the(More)
OBJECTIVE This study examined associations of asthma management-related beliefs and behaviors with immune markers and clinical outcomes in a sample of 66 children with asthma (ages 9-18 years). METHODS Children and parents were interviewed about asthma management beliefs and behaviors. Immune measures included stimulated production of cytokines implicated(More)
Catechol-O-Methyltransferase (COMT) activity was studied in three groups of institutionalized children: (1) a group of schizophrenic children; (2) a heterogeneous group of chronic psychotic children characterized by severe symptomatology and onset before 5 years of age; (3) a group of acting-out but nonpsychotic children. Erythrocyte COMT activity was found(More)