Hoo-Kyun Choi

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Novel signaling components of dopamine D3 receptor (D3R) were searched using yeast two-hybrid system, and the gamma subunit of elongation Factor-1B (eEF1Bgamma) was found to interact with D3R. This interaction was observed specifically between eEF1Bgamma and D3R but not with D2R or D4R. Immunocytochemical studies showed that D3R and eEF1Bgamma form clusters(More)
Solid lipid nanoparticles (SLN) loaded with doxorubicin were prepared by solvent emulsification-diffusion method. Glyceryl caprate (Capmul)MCM C10) was used as lipid core, and curdlan as the shell material. Dimethyl sulfoxide (DMSO) was used to dissolve both lipid and drug. Polyethylene glycol 660 hydroxystearate (Solutol)HS15) was employed as surfactant.(More)
Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, eBooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8(More)
  • Jung Hyun Han, Hoo-Kyun Choi, Seong J Kim
  • 2012
Pruritus vulvae is caused by a variety of skin diseases, as well as by neuropathic/neurological, psychosomatic and psychiatric diseases. It is difficult to determine the pathogenesis of itching symptoms over the vulval area, but ongoing inflammatory reactions, may be responsible for lowering the perception threshold of itching (1, 2). A variety of topical(More)
Selegiline transdermal drug delivery system (TDDS) of drug-in-adhesive matrix type was developed using acrylic-rubber hybrid pressure sensitive adhesive (PSA). The permeation rate of selegiline was the highest from silicone, followed by acrylic-rubber hybrid, acrylics. Although the permeation rate of silicone PSA was higher than that of acrylic-rubber(More)
It is my great pleasure and honor to guest edit this special issue of Journal of Pharmaceutical Investigation, 2016. All the authors who participated in the issue are prominent scientists in each field. The theme of this issue is ''Spe-cialized drug delivery systems.'' We may have had more than enough of this topic. Nonetheless, the reason I chose the topic(More)
The purpose of this study was to investigate the feasibility of developing transdermal drug delivery system for ketotifen used for asthma, allergic conjunctivitis, and rhinitis. The permeation of ketotifen in silicone, polyisobutylene, styrene–butadiene–styrene and acrylic-rubber hybrid and acrylic pressure sensitive adhesive matrix was evaluated. Due to(More)
A novel transdermal drug delivery system with the eutectic mixture of lidocaine and prilocaine was developed. The permeation of lidocaine and prilocaine proportionally increased as the weight ratio of poly(vinyl alcohol) to poly(acrylic acid) changed from 1:1 to 7:1. However, the adhesive property of the matrix significantly degraded over the ratio of 5:1.(More)
The effects of different formulation variables on the transdermal absorption of donepezil were investigated. The permeation of donepezil from various pressure sensitive adhesive matrices was evaluated using flow-through diffusion cell system at 37°C. The penetration of donepezil from the matrices was found to be influenced by the nature of adhesives. 1:1(More)
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