Hoo-Kyun Choi

Myung-Kwan Chun4
Cheol Moon1
Jae-Sang Chang1
4Myung-Kwan Chun
1Cheol Moon
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Novel signaling components of dopamine D3 receptor (D3R) were searched using yeast two-hybrid system, and the gamma subunit of elongation Factor-1B (eEF1Bgamma) was found to interact with D3R. This interaction was observed specifically between eEF1Bgamma and D3R but not with D2R or D4R. Immunocytochemical studies showed that D3R and eEF1Bgamma form clusters(More)
Selegiline transdermal drug delivery system (TDDS) of drug-in-adhesive matrix type was developed using acrylic-rubber hybrid pressure sensitive adhesive (PSA). The permeation rate of selegiline was the highest from silicone, followed by acrylic-rubber hybrid, acrylics. Although the permeation rate of silicone PSA was higher than that of acrylic-rubber(More)
The purpose of this study was to investigate the feasibility of developing transdermal drug delivery system for ketotifen used for asthma, allergic conjunctivitis, and rhinitis. The permeation of ketotifen in silicone, polyisobutylene, styrene–butadiene–styrene and acrylic-rubber hybrid and acrylic pressure sensitive adhesive matrix was evaluated. Due to(More)
The effects of different formulation variables on the transdermal absorption of donepezil were investigated. The permeation of donepezil from various pressure sensitive adhesive matrices was evaluated using flow-through diffusion cell system at 37°C. The penetration of donepezil from the matrices was found to be influenced by the nature of adhesives. 1:1(More)
A novel transdermal drug delivery system with the eutectic mixture of lidocaine and prilocaine was developed. The permeation of lidocaine and prilocaine proportionally increased as the weight ratio of poly(vinyl alcohol) to poly(acrylic acid) changed from 1:1 to 7:1. However, the adhesive property of the matrix significantly degraded over the ratio of 5:1.(More)
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